220030-60-4Relevant articles and documents
Synthesis of photoaffinity probes for heme-containing proteins
Tschirret-Guth, Richard A.,De Ortiz Montellano, Paul R.
, p. 9711 - 9715 (1998)
Aryldiazenes with a second, photoactivatable, azide substituent on the aryl ring have been synthesized as active site probes for heme proteins of unknown active site structure. The probes include most of the possible isomers of the phenyl, naphthyl, and biphenyl ring systems. A selection of the probes has been shown to react with the model protein P450(cam) to give (arylazido)iron (Fe-ArN3) complexes, a prerequisite for subsequent affinity labeling of the protein.
