220352-36-3 Usage
Description
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is an organic compound characterized by its cyclopropane ring and difluorophenyl group. It is a chiral molecule with specific stereochemistry at the first and second carbon atoms, denoted as (1R,2R). (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is used as an intermediate for the preparation of AZD6140, an orally active reversible P2Y12 receptor antagonist. This application is significant for the prevention of thrombosis, a condition characterized by the formation of blood clots within the circulatory system, which can lead to serious health complications such as heart attacks and strokes.
Additionally, (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid is used in the synthesis of triazolopyrimidine derivatives, which act as P2T receptor antagonists. These derivatives have potential applications in the treatment of various diseases and disorders, highlighting the versatility of this intermediate in the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 220352-36-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,3,5 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 220352-36:
(8*2)+(7*2)+(6*0)+(5*3)+(4*5)+(3*2)+(2*3)+(1*6)=83
83 % 10 = 3
So 220352-36-3 is a valid CAS Registry Number.
220352-36-3Relevant articles and documents
Preparation method of phenyl-containing compound
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Paragraph 0106-0111, (2022/01/04)
The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr
Preparation method of ticagrelor key intermediate
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Paragraph 0013, (2020/05/08)
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a ticagrelor key intermediate, and the method is used for preparing the ticagrelor intermediate, has the advantages of short reaction steps, mild reaction conditions and higher yield than the existing preparation method, is economical and effective, and is suitable for large-scale industrial production.
Preparation method of ticagrelor
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Paragraph 0035; 0037; 0040; 0044; 0084; 0125, (2018/04/21)
The invention discloses a preparation method of ticagrelor. The preparation method comprises the following steps: (1) preparation of ticagrelor intermediate product 1-TK acid; (2) preparation of ticagrelor intermediate product 2-TK-amide; (3) preparation of ticagrelor intermediate product 3-TK-amino compound hydrochloride; (4) preparation of ticagrelor intermediate product 4-TK-amino compound R-tartrate; ( 5) preparation of ticagrelor intermediate product 5-TK-amino compound L-mandelate; and (6) preparation of ticagrelor-TK. The preparation method has the advantages of cost advantage, mature and stable process, stable product quality, and safe and reliable production process.