220365-00-4

Basic information

• Product Name: 7-(2-oxo-2-phenylethoxy)quinolin-2(1H)-one
• Synonyms: 7-(2-oxo-2-phenylethoxy)quinolin-2(1H)-one
• CAS NO: 220365-00-4
• Molecular Weight: 279.295
• Mol File: 220365-00-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(2-oxo-2-phenylethoxy)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(2-oxo-2-phenylethoxy)quinolin-2(1H)-one(220365-00-4)
• EPA Substance Registry System: 7-(2-oxo-2-phenylethoxy)quinolin-2(1H)-one(220365-00-4)

Safety Data

• Hazardous Substances Data: 220365-00-4(Hazardous Substances Data)

Upstream product

• 70500-72-0 7-hydroxy-1H-quinolin-2-one 
• 70-11-1 α-bromoacetophenone 
• 220364-99-8 2-oxo-1,2-dihydroquinolin-7-yl-acetate 
• 93499-67-3 7-hydroxyquinoline 1-oxide 

Relevant articles and documents

Synthesis of certain quinolin-2(1H)-one α-methylene-γ-butyrolactones as potential antiplatelet agents

Certain quinolin-2(1H)-one derivatives with various α-methylene-γ- butyrolactones substituted at C(7)-position were synthesized and evaluated for their antiplatelet activity against arachidonic acid (AA)-, and platelet- activating factor (PAF)-induced aggregation in washed rabbit platelets. 7- Hydroxyquinoline 1-oxide was treated with acetic anhydride followed by the hydrolysis of 1.0 N NaOH to afford 7-hydroxyquinolin-2(1H)-one (6). The desired 7-[(2,3,4,5-tetrahydro-4-methylene-5-oxo-2-furanyl)methoxy]-quinolin- 2(1H)-ones (8a-e) were obtained from 6 via alkylation and the Reformatsky- type condensation. These quinolin-2(1H)-ones (8a-e), exhibited approximately five to seven times more potent than their coumarin counterparts against AA- and PAF-induced aggregation and are approximately two hundred times more potent than aspirin against AA-induced aggregation.