220384-49-6

Basic information

• Product Name: (2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 220384-49-6
• Molecular Weight: 211.304
• Mol File: 220384-49-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester(220384-49-6)
• EPA Substance Registry System: (2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester(220384-49-6)

Safety Data

• Hazardous Substances Data: 220384-49-6(Hazardous Substances Data)

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 134526-69-5 tert-butoxycarbonyl-D-piperidine-2-carboxaldehyde 
• 893430-03-0 (R)-5-azido-7-(tert-butyldiphenylsilyloxy)heptanal 
• 893430-06-3 (R)-5-azido-7-(tert-butyldiphenylsilyloxy)heptanoic acid 
• 893430-07-4 (R)-6-[2-(tert-butyldiphenylsilyloxy)ethyl]-2-piperidinone 
• 893430-09-6 (R)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine 
• 893442-85-8 tert-butyl (R)-2-[2-(tert-butyldiphenylsilyloxy)ethyl]piperidine-1-carboxylate 
• 893430-01-8 (R)-3-azido-1-(tert-butyldiphenylsilyloxy)-7-trityloxyheptane 
• 893430-02-9 (R)-5-azido-7-(tert-butyldiphenylsilyloxy)-1-heptanol 
• 73229-30-8 hepta-5,6-diene-1-ol 
• 928-90-5 5-hexyl-1-ol 
• 107970-42-3 N-(hepta-5,6-dien-1-yl)-4-methylbenzenesulfonamide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 475995-17-6 (S)-1-(tert-butyldiphenylsilyloxy)-7-trityloxyheptan-3-ol 

Downstream Products

• 56293-29-9 (+)-aloperine 
• 220384-61-2 (6R,7R,13R,14R,15S)-14-hydroxy-1-(p-toluenesulfonyl)-tetradecahydro-6,13-methano-dipyrido<1,2-a;3',2'-e>azocin-12-one 
• 220384-63-4 (6R,7R,13S,15S)-1-(p-toluenesulfonyl)-tetradecahydro-6,13-methano-dipyrido<1,2-a;3',2'-e>azocin-12-one 
• 220384-58-7 5-((E)-(R)-2-Piperidin-2-yl-vinyl)-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-pyridine 
• 220384-57-6 (2R)-2-<(1E)-2-<1-(p-toluenesulfonyl)-1,4,5,6-tetrahydropyridin-3-yl>-vinyl>-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Allenes

The rhodium-catalyzed asymmetric intramolecular hydroamination of sulfonyl amides with terminal allenes is reported. It provides selective access to 5- and 6-membered N-heterocycles, scaffolds found in a large range of different bioactive compounds. Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof are demonstrated.

Synthesis of an optically pure synthetic intermediate of aloperine from a yeast-reductive product

Optically pure (S)- and (R)-vinylpiperidine 2 and (S)-and (A)-(hydroxyethyl)piperidine 3, which were key intermediates for the synthesis of aloperine, were synthesized from yeast-reductive products.