220448-44-2

Basic information

• Product Name: 2-Propenoic acid, 2-azido-3-(2-bromophenyl)-, methyl ester
• CAS NO: 220448-44-2
• Molecular Formula: C10H8BrN3O2
• Molecular Weight: 282.096
• Mol File: 220448-44-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-azido-3-(2-bromophenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-azido-3-(2-bromophenyl)-, methyl ester(220448-44-2)
• EPA Substance Registry System: 2-Propenoic acid, 2-azido-3-(2-bromophenyl)-, methyl ester(220448-44-2)

Safety Data

• Hazardous Substances Data: 220448-44-2(Hazardous Substances Data)

Upstream product

• 637-81-0 ethyl-2-azidoacetate 
• 124-41-4 sodium methylate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1816-92-8 Methyl azidoacetate 

Downstream Products

• 1362861-28-6 11-(4-hydroxyphenyl)chromeno[3,4-b]indole-6(7H)-one 
• 1362861-29-7 2-hydroxy-11-(4-hydroxyphenyl)chromeno[3,4-b]indole-6(7H)-one 
• 1362861-01-5 methyl 4-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 1362861-03-7 methyl 3-iodo-4-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 1362861-10-6 methyl 3-(2-methoxyphenyl)-4-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 1362861-11-7 methyl 3-(2,5-dimethoxyphenyl)-4-(4-methoxyphenyl)-1H-indole-2-carboxylate 
• 167479-13-2 4-bromo-1H-indole-2-carboxylic acid methyl ester 
• 1158503-82-2 C₁₀H₈BrNO₂ 

Relevant articles and documents

Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry

Microwave, flow and combination methodologies have been applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodology allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chemistry, allowing formation of peptide adducts which can be subsequently labeled with fluorine tags.