220464-84-6

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(4-chlorophenoxy)-
• CAS NO: 220464-84-6
• Molecular Formula: C14H8ClNO3
• Molecular Weight: 273.675
• Mol File: 220464-84-6.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-chlorophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(4-chlorophenoxy)-(220464-84-6)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(4-chlorophenoxy)-(220464-84-6)

Safety Data

• Hazardous Substances Data: 220464-84-6(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 36637-30-6 O-(4-chlorophenyl)hydroxylamine 
• 88-95-9 Phthaloyl dichloride 

Downstream Products

• 607-12-5 5-chloro-biphenyl-2-ol 
• 80460-34-0 2-(5-chloro-2-hydroxy-phenyl)-isoindole-1,3-dione 
• 891-15-6 5-chloro-2-(4-methoxyphenyl)benzo[d]oxazole 
• 1166839-38-8 4-methoxybenzaldehyde O-4-chlorophenyl oxime 
• 51589-62-9 2-(2'-Hydroxy-5'-chlorophenyl)benzoxazole 
• 26488-93-7 N-(5-chloro-2-hydroxyphenyl)acetamide 
• 85-19-8 (5-chloro-2-hydroxyphenyl)phenylmethanone 
• 92829-67-9 p-chlorophenyloxyamine hydrochloride 
• 36637-30-6 O-(4-chlorophenyl)hydroxylamine 

Relevant articles and documents

Cobalt(III)-Catalyzed Enantioselective Intermolecular Carboamination by C?H Functionalization

High-valent cyclopentadienyl cobalt catalysis is a versatile tool for sustainable C?H bond functionalizations. To harness the full potential of this strategy, control of the stereoselectivity of these processes is necessary. Herein, we report highly enant

An internal oxidant-directing strategy enabling transition metal-free C–S bond ligation

Organic sulfur compounds have broad applications in biology, medicine and material sciences and intensive efforts have been devoted to developing mild and general C–S bond-forming methods. However, a mild, transition-metal-free, direct C–H bond functionalization method remains elusive. Here, we report the use of an internal oxidant-directing strategy to achieve this goal. The cascade reactions described here show excellent chemoselectivity and a wide substrate scope for both oxyamines and sulfenylation reagents. This study enlarges the synthesis toolbox for preparing structurally diverse sulfilimines under mild conditions.

Rh(III)-Catalyzed Redox-Neutral Unsymmetrical C-H Alkylation and Amidation Reactions of N-Phenoxyacetamides

A Rh(III)-catalyzed unsymmetrical C-H alkylation and amidation of N-phenoxyacetamides with diazo compounds has been developed under mild and redox-neutral conditions, producing dinitrogen as the only byproduct. The reaction represents the first example of one-step, unsymmetrical difunctionalization of two ortho-C-H bonds. Experimental and computational studies support that N-phenoxyacetamides most likely undergo an initial ortho-C-H alkylation with diazo compounds via a Rh(III)-catalyzed C-H activation, and the resulting Rh(III) intermediate subsequently undergoes an intramolecular oxidative addition into the O-N bond to form a Rh(V) nitrenoid species that is protonated and further directed toward electrophilic addition to the second ortho position of the phenyl ring. This work might provide a new direction for unsymmetrical C-H difunctionalization reactions in an efficient manner.