22050-11-9Relevant articles and documents
Synthetic method of pyrrole derivatives
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Paragraph 0079-0083, (2017/04/22)
The invention provides a synthetic method of pyrrole derivatives, comprising the steps of: successively adding amine, electron-withdrawing alkyne and olefin in a reaction container according to the molar ratio of 1:1-1.4:1.3-4, adding in the solvent according to the ratio of 1mmol of amine added in 2-4mL of solvent, and then adding 0.8-2% molar ratio of catalyst Pd(OAc)2, 1.8-4% amine molar ratio of oxidizing agent K2S2O8, 2mL of acetic acid and 2mL of hexanenitrile; reacting for 15-24h at 100oC-120oC of oilbath; cooling to room temperature, adding water, extracting for three times by ethyl acetate, combining an organic layer, decompressing and concentrating, carrying out column chromatography and purification to the product, and obtaining the product of pyrrole derivatives. The method provided in the invention has simple reaction and operation, cheap reaction substrate, high yield, good selection, easy separation and purification and little pollution.
Microwave-assisted catalyst-free synthesis of tetrasubstituted pyrroles using dialkyl acetylenedicarboxylates and monophenacylanilines
Mariappan, Arumugam,Rajaguru, Kandasamy,Muthusubramanian, Shanmugam,Bhuvanesh, Nattamai
supporting information, p. 805 - 812 (2016/07/06)
An efficient catalyst-free microwave-assisted synthesis of tetrasubstituted pyrroles using dialkyl acetylenedicarboxylates and substituted monophenacylanilines has been developed. Axial chirality has been noticed in some N-(α-naphthyl/2-isopropylphenyl)-2