22059-21-8Relevant articles and documents
Thermally induced and transition metal catalyzed aza-Claisen rearrangement of 2-cyclopropylideneethyl imidates: A new entry to 1-aminocyclopropanecarboxylic acids
Estieu, Karine
, p. 2975 - 2977 (1995)
(2-Cyclopropylideneethyl) acetimidates underwent thermally induced or palladium (II) catalyzed azaClaisen rearrangement into 1-ethenylcyclopropyl acetamides, providing convenient precursors to 1-amino cyclopropanecarboxylic acids (ACCs). Due to the regioselectivity of the nucleophilic substitution of the π 1,1-dimethylene allyl palladium complexes by soft nucleophiles, the palladium (0) catalysis was apparently non effective.
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Kollonitsch,J. et al.
, p. 771 - 777 (1979)
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PRODUCTION METHOD FOR 1-AMINO CYCLOPROPANE CARBOXYLIC ACID NONHYDRATE
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Paragraph 0050-0052, (2021/05/14)
1-Aminocyclopropanecarboxylic acid non-hydrate can be obtained by treating 1-aminocyclopropanecarboxylic acid hydrochloride with a tertiary amine in the presence of a C3-C4 alcohol and water, keeping the reaction mixture at 50° C. or below, collecting the precipitated crystal of 1-aminocyclopropanecarboxylic acid 0.5 hydrate by filtration, and contacting the obtained crystal with a C1-C2 alcohol.
Preparation method of 1-amino-cyclopropanecarboxylic acid
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Paragraph 0012; 0014; 0016; 0018, (2018/03/26)
The invention discloses a preparation method of 1-amino-cyclopropanecarboxylic acid. The method includes: adopting nitroacetonitrile as the starting material, carrying out cyclization and hydrolysis reaction with 1, 2-dibromoethane under the action of potassium carbonate and the phase transfer catalyst tetrabutylammonium bromide to obtain 1-nitro-cyclopropanecarboxylic acid, and then carrying outnitro reduction reaction under the action of a palladium carbon catalyst and hydrogen to obtain 1-amino-cyclopropanecarboxylic acid. The method provided by the invention adopts the new starting material, achieves one-pot two-step reaction of cyclization and hydrolysis, has the advantages of short reaction step, high yield, high product purity and low cost, and is suitable for industrial application.
A 1-amino-cyclopropane-1-carboxylic acid simple synthesis process
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Paragraph 0023; 0024, (2017/02/24)
The invention relates to a synthesis process of 1-aminocyclopropane-1-carboxylic acid. According to the process, the 1-aminocyclopropane-1-carboxylic acid is synthesized from nitro acetate and 1,2-dihalo ethane through the reaction of alkylated cyclization, nitro reduction and carboxyl hydrolysis, and a high-content and high-purity product is obtained through carrying out separation, purification and crystallization after the reaction is ended. In the aspects of reagents and raw and auxiliary materials used during the reaction, both environment-friendliness and efficiency are taken into account. The process disclosed by the invention has the advantages of high atom economical efficiency, simple equipment and environment-friendly production procedure and has very large economic and social benefits.