220707-94-8

Basic information

• Product Name: 3-(3,4-dichlorophenyl)prop-2-yn-1-ol
• Synonyms: 3-(3,4-dichlorophenyl)prop-2-yn-1-ol
• CAS NO: 220707-94-8
• Molecular Formula: C₉H₆Cl₂O
• Molecular Weight: 201.05
• Mol File: 220707-94-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 314.812 °C at 760 mmHg
• Flash Point: 127.406 °C
• Appearance: /
• Density: 1.41
• CAS DataBase Reference: 3-(3,4-dichlorophenyl)prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dichlorophenyl)prop-2-yn-1-ol(220707-94-8)
• EPA Substance Registry System: 3-(3,4-dichlorophenyl)prop-2-yn-1-ol(220707-94-8)

Safety Data

• Hazardous Substances Data: 220707-94-8(Hazardous Substances Data)

Usage

General Description

3-(3,4-dichlorophenyl)prop-2-yn-1-ol, also known as 3,4-dichloro-alpha,omega-diphenylpropadien-1-ol, is a chemical compound with the molecular formula C9H6Cl2O. It is a white to off-white crystalline solid that is soluble in organic solvents. 3-(3,4-dichlorophenyl)prop-2-yn-1-ol is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also known to possess antimicrobial and antifungal properties. Additionally, it is utilized in the production of specialty chemicals and industrial materials. However, it is important to handle this compound with care due to its potential hazards, including irritant and harmful effects if ingested or inhaled.

Upstream product

• 20555-91-3 3,4-dichloroiodobenzene 
• 107-19-7 propargyl alcohol 

Downstream Products

• 1010684-85-1 3-(3,4-dichlorophenyl)prop-2-yn-1-al 
• 39960-05-9 3-(3 ,4-dichlorophenyl)propan-1-ol 
• 1628200-44-1 1,2-dichloro-4-(1,1,1-trifluorobuta-2,3-dien-2-yl)benzene 
• 1628200-55-4 3-(3,4-dichlorophenyl)prop-2-yn-1-yl 2-bromo-2,2-difluoroacetate 

Relevant articles and documents

Nickel(II)-Catalyzed Asymmetric Propargyl [2,3] Wittig Rearrangement of Oxindole Derivatives: A Chiral Amplification Effect

A highly enantioselective [2,3] Wittig rearrangement of oxindole derivatives was realized by using a chiral N,N′-dioxide/NiII complex as the catalyst under mild reaction conditions. A strong chiral amplification effect was observed, and allowed access to chiral 3-hydroxy 3-substituted oxindoles bearing allenyl groups in high yields and enantioselectivities (up to 92 % ee) by using a ligand with only 15 % ee. A reasonable explanation was given based on the experimental investigations and X-ray crystal structures of enantiomerically pure and racemic catalysts. Moreover, the first catalytic kinetic resolution of racemic oxindole derivatives by a [2,3] Wittig rearrangement was realized with high efficiency and stereoselectivity.

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

NOVEL ARYLBICYCLO[3.1.0]HEXYLAMINES AND METHODS AND COMPOSITIONS FOR THEIR PREPARATION AND USE

The invention provides novel arylbicyclo[3.1.OJhexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system