220760-85-0

Basic information

• Product Name: 2-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester
• CAS NO: 220760-85-0
• Molecular Weight: 928.775
• Mol File: 220760-85-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester(220760-85-0)
• EPA Substance Registry System: 2-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester(220760-85-0)

Safety Data

• Hazardous Substances Data: 220760-85-0(Hazardous Substances Data)

Upstream product

• 162599-95-3 (R)-3-(3-Chloro-4-methoxy-phenyl)-2-((2E,7E)-(5S,6R)-5-hydroxy-6-methyl-8-phenyl-octa-2,7-dienoylamino)-propionic acid 2,2,2-trichloro-ethyl ester 
• 220760-72-5 2-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 1-carboxy-3-methyl-butyl ester 
• 220760-49-6 N-tert-butoxycarbonyl-1-aminocyclohexane-2-carboxylic acid 
• 220760-56-5 2-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 1-allyloxycarbonyl-3-methyl-butyl ester 

Downstream Products

• 220760-95-2 2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester 
• 220761-03-5 (E)-(7R,13S,16S)-7-(3-Chloro-4-methoxy-benzyl)-16-isobutyl-13-((E)-(R)-1-methyl-3-phenyl-allyl)-1,3,4,4a,5,7,8,12,13,18a-decahydro-2H-14,17-dioxa-5,8-diaza-benzocyclohexadecene-6,9,15,18-tetraone 

Relevant articles and documents

Synthesis and Biological Evaluation of Novel Cryptophycin Analogs with Modification in the β-Alanine Region

Structure modification of the β-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (β-alanine) with various (l)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.