22084-89-5

Basic information

• Product Name: 3-(2-METHYLPHENYL)PROPIONIC ACID
• Synonyms: 3-(2-Methylphenyl)propanoic acid;3-(2-METHYLPHENYL)PROPIONIC ACID;2-METHYLHYDROCINNAMIC ACID;3-o-Tolylpropanoic acid;3-(2-Methylphenyl)propionic acid ,99%;2-Methylhydrociamic acid;Benzenepropanoic acid, 2-Methyl-;2-Methyl-benzenepropanoic acid
• CAS NO: 22084-89-5
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Product Categories: C10;Carbonyl Compounds;Carboxylic Acids
• Mol File: 22084-89-5.mol
• Article Data: 23

Chemical Properties

• Melting Point: 100-103 °C(lit.)
• Boiling Point: 293.3 °C at 760 mmHg
• Flash Point: 190.5 °C
• Appearance: /
• Density: 1.097g/cm³
• Vapor Pressure: 0.000792mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:4.66 (25°C)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 3-(2-METHYLPHENYL)PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-METHYLPHENYL)PROPIONIC ACID(22084-89-5)
• EPA Substance Registry System: 3-(2-METHYLPHENYL)PROPIONIC ACID(22084-89-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 22084-89-5(Hazardous Substances Data)

Usage

Description

3-(2-METHYLPHENYL)PROPIONIC ACID, also known as 2-Methylhydrocinnamic acid, is a carboxylic acid building block derived from hydrolyzable tannins found in various plant sources. It possesses weak acidic properties and plays a crucial role in the synthesis of 2-methyl-3-phenylpropanol, a compound with potential applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
3-(2-METHYLPHENYL)PROPIONIC ACID is used as a building block for the synthesis of 2-methyl-3-phenylpropanol, which is an essential component in the development of various pharmaceutical compounds. The synthesis of this compound contributes to the creation of new drugs with potential therapeutic applications.
Used in Chemical Industry:
3-(2-METHYLPHENYL)PROPIONIC ACID is used as a key intermediate in the chemical industry for the production of various organic compounds, including 2-methyl-3-phenylpropanol. 3-(2-METHYLPHENYL)PROPIONIC ACID serves as a valuable precursor in the synthesis of other chemicals, which can be utilized in a wide range of applications, such as the manufacturing of fragrances, flavors, and other specialty chemicals.

InChI:InChI=1/C10H12O2/c1-8-4-2-3-5-9(8)6-7-10(11)12/h2-5H,6-7H2,1H3,(H,11,12)

Upstream product

• 6619-57-4 diethyl 2-(2-methylbenzyl)-malonate 
• 939-57-1 (E)-3-(2-methylphenyl)acrylic acid 
• 2373-76-4 2-methylcinnamic acid 
• 7363-85-1 3-(2-methylcyclohex-1-en-1-yl)propanoic acid 
• 57-57-8 β-Propiolactone 
• 95-46-5 2-methylphenyl bromide 
• 107-94-8 chloropropionic acid 
• 108-88-3 toluene 
• 78606-96-9 <(2-methylphenyl)methyl>propanedioic acid 
• 3984-22-3 2-vinyl-1,3-dioxolane 
• 103-83-3 N,N'-dimethylbenzylamine 
• 2495-35-4 benzylacrylate 
• 929557-06-2 benzyl 3-(o-tolyl)propanoate 
• 552-45-4 1-chloromethyl-2-methylbenzene 

Downstream Products

• 24644-78-8 4-methylindanone 
• 104750-61-0 ethyl 3-(o-tolyl)propanoate 
• 85829-29-4 3-(2-methylphenyl)propionic acid chloride 
• 14902-36-4 3-(2-methylphenyl)-1-propanol 
• 42817-56-1 dimethyl-(3-o-tolyl-propyl)-amine 
• 26465-81-6 3,3-dimethylindan-1-one 
• 37741-54-1 β-(2-tolyl)propionic acid methyl ester 
• 4242-15-3 5-methyl-2-tetralone 
• 90266-00-5 1-Diazo-4-(2-methylphenyl)butan-2-one 
• 365554-24-1 2-amino-5-methyl-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid 
• 952315-92-3 dimethyl 4-(2-methylphenyl)-2-oxobutylphosphonate 

Relevant articles and documents

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Photoredox Activation of Formate Salts: Hydrocarboxylation of Alkenes via Carboxyl Group Transfer

A photoredox activation mode of formate salts for carboxylation was developed. Using a formate salt as the reductant, carbonyl source, and hydrogen atom transfer reagent, a wide range of alkenes can be converted into acid products via a carboxyl group tra

Method for selective reduction α, β - unsaturated carbonyl compound carbon-carbon double bond (by machine translation)

The invention discloses a method for selectively reducing carbon-carbon double bonds in α and β - unsaturated carbonyl compounds, which comprises the following steps of adding α, β - unsaturated carbonyl compounds shown in formula (I) in an electrolysis system and reducing α and β - unsaturated carbonyl compounds with carbonyl-conjugated carbon-carbon double bonds through an electrochemical cathodic reduction reaction. Compared with the reported method, the method disclosed by the invention does not use a metal catalyst and an external oxidant; and the reaction raw material and the electrolyte are low in price, nontoxic and tasteless, simple and convenient in post-treatment. (by machine translation)

Regioselectivity inversion tuned by iron(iii) salts in palladium-catalyzed carbonylations

Impactful regioselectivity control is crucial for cost-effective chemical synthesis. By using cheap and abundant iron(iii) salts, the hydroxycarbonylations of both aromatic and aliphatic alkenes were significantly enhanced in both reactivity and selectivity (iso/n or n/iso up to >99:1). Moreover, Pd-catalyzed carbonylation selectivity can be switched from branched to linear by using different Fe(iii) salts. In addition, similar results were obtained for the carbonylation of secondary alcohols.