220987-97-3Relevant articles and documents
Substituted benzene compounds as antiproliferative and cholesterol lowering action
-
, (2008/06/13)
The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease st
Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells
Medina, Julio C.,Roche, Daniel,Shan, Bei,Learned, R. Marc,Frankmoelle, Walter P.,Clark, David L.,Rosen, Terry,Jaen, Juan C.
, p. 1843 - 1846 (2007/10/03)
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of β-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.