221246-34-0

Basic information

• Product Name: 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA
• Synonyms: 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-TRIFLUOROMETHYLPHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID;17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA;17-trifluoromethylphenyl trinor Prostaglandin F2α;CMLNDCUXASGBMQ-NQUQXYBYSA-N
• CAS NO: 221246-34-0
• Molecular Formula: C₂₄H₃₁F₃O₅
• Molecular Weight: 456.5
• Mol File: 221246-34-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 593.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.296±0.06 g/cm3(Predicted)
• PKA: 4.76±0.10(Predicted)
• CAS DataBase Reference: 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA(CAS DataBase Reference)
• NIST Chemistry Reference: 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA(221246-34-0)
• EPA Substance Registry System: 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA(221246-34-0)

Safety Data

• Hazardous Substances Data: 221246-34-0(Hazardous Substances Data)

Usage

Description

17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA, also known as 17-trifluoromethylphenyl trinor PGF2α, is a derivative of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α). It is a potent compound with an aromatic ring similar to the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA has been found to be effective in various applications, particularly in the medical field.

Uses

Used in Ophthalmology:
17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA is used as an ocular hypotensive agent for the treatment of glaucoma. As an FP receptor agonist, it acts similarly to the free acid of travoprost, effectively reducing intraocular pressure and managing glaucoma symptoms.
Used in Veterinary Medicine:
In the veterinary industry, 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA is used as a potent luteolytic and abortifacient agent. It is effective in inducing luteal regression and abortion, with a potency equal to or greater than fluprostenol and cloprostenol, making it a valuable tool in reproductive management for various animal species.

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Relevant articles and documents

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chin aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF(2α). (C) 2000 Published by Elsevier Science Ltd.