22126-67-6

Basic information

• Product Name: Naphazoline IMpurity D
• Synonyms: Naphazoline IMpurity D;Naphazoline EP Impurity D;2-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole
• CAS NO: 22126-67-6
• Molecular Formula: C14H14N2
• Molecular Weight: 210.27
• Mol File: 22126-67-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• CAS DataBase Reference: Naphazoline IMpurity D(CAS DataBase Reference)
• NIST Chemistry Reference: Naphazoline IMpurity D(22126-67-6)
• EPA Substance Registry System: Naphazoline IMpurity D(22126-67-6)

Safety Data

• Hazardous Substances Data: 22126-67-6(Hazardous Substances Data)

Usage

Description

Naphazoline IMpurity D, also known as 2-(Naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole, is an impurity compound derived from Naphazoline (N343950, N756953). It is characterized by its chemical structure, which features a naphthalene group and an imidazole ring, and is used as an intermediate in the synthesis of various compounds.

Uses

Used in Pharmaceutical Industry:
Naphazoline IMpurity D is used as an intermediate for the preparation of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives. These derivatives possess antidepressant properties, making them valuable in the development of new treatments for depression and other mood disorders.
Used in Chemical Research:
In addition to its pharmaceutical applications, Naphazoline IMpurity D may also be utilized in chemical research for the synthesis of other complex organic compounds. Its unique structure and reactivity make it a potentially useful building block in the development of new molecules with diverse applications.

Upstream product

• 7498-57-9 2-naphthaleneacetonitrile 
• 107-15-3 ethylenediamine 

Relevant articles and documents

Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives

A unique combination of α2-adrenoreceptor antagonist and serotonin-selective reuptake inhibitory activities has been identified in a series of 2-substituted 4,5-dihydro-1H-imidazole derivatives. This combination of blocking activities has provided one of these derivatives, napamezole hydrochloride (2), with potential as an antidepressant. A discussion of the syntheses of these compounds includes a convenient method for the conversion of nitriles to imidazolines with ethylenediamine and trimethylaluminum.

Benzylamidine derivatives with serotonin receptor binding activity

This invention relates to compounds having serotonin receptor binding activity, to pharmaceutical compositions containing them and to their medical use, particularly in the treatment of CNS conditions. Described herein are compounds which have the general formula: STR1 wherein R 1 is selected from a group of Formula i and ii: STR2 n is 1-3; R 2 is selected from H and C 1-6 alkyl;R 3 is selected from H and C 1-6 alkyl;R 4 is selected from C 1-6 alkyl, halo, phenyl, amino and nitro;R 5 is selected from H, C 1-6 alkyl and arylalkyl;R 6 is selected from H or a alkylene group which is bonded to R 4 to form the naphthalene ring skeleton; and salts, hydrates and solvates thereof.Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of subtypes of the serotonin receptor is implicated, such as migraine.