22157-27-3

Basic information

• Product Name: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-
• Synonyms: 2-Butenoicacid, 3-methoxy-, ethyl ester, (E)-; Crotonic acid, 3-methoxy-, ethyl ester,(E)- (8CI); (2E)-3-Methoxybut-2-enoic acid ethyl ester; Ethyl(E)-3-methoxy-2-butenoate; Ethyl (E)-3-methoxycrotonate; Methyl (E)-b-methoxymethacrylate; NSC 165534
• CAS NO: 22157-27-3
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.1684
• Mol File: 22157-27-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 188.6°Cat760mmHg
• Flash Point: 69.3°C
• Density: 0.978g/cm³
• CAS DataBase Reference: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-(22157-27-3)
• EPA Substance Registry System: 2-Butenoic acid,3-methoxy-, ethyl ester, (2E)-(22157-27-3)

Safety Data

• Hazardous Substances Data: 22157-27-3(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 141-97-9 ethyl acetoacetate 
• 66279-50-3 ethylacetoacetate, K(+) salt 
• 80-48-8 methyl p-toluene sulfonate 
• 67-56-1 methanol 
• 149-73-5 trimethyl orthoformate 
• 64-17-5 ethanol 
• 121781-82-6 5-(1-methoxyethylene) Meldrum's acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 112165-31-8 5-(4-bromophenyl)-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-28-3 5-(4-bromophenyl)-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 112331-01-8 (2E,4E)-5-(2,6-Dichloro-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 69813-36-1 3-methoxy-5-phenyl-2(E),4(E)-pentadienoic acid 
• 112330-94-6 (2E,4E)-3-Methoxy-5-(4-methoxy-phenyl)-penta-2,4-dienoic acid 
• 112330-95-7 (2E,4E)-5-(3,4-Dimethoxy-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 112165-29-4 5-phenyl-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-26-1 5-phenyl-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 112165-30-7 5-(4-methylphenyl)-5-methyl 3-methoxy-(2E,4Z)-pentadienoic acid 
• 112165-27-2 5-(4-methylphenyl)-5-methyl 3-methoxy-(2E,4E)-pentadienoic acid 
• 112330-98-0 (2E,4E)-5-(3,4-Dichloro-phenyl)-3-methoxy-penta-2,4-dienoic acid 
• 75668-75-6 N-(1-Ethoxycarbonyl-2-methoxy-2-propenylsulfinyl)-p-toluolsulfonamid 
• 67107-76-0 3-methoxy-2-butenoic acid 
• 561276-74-2 (+)-(E,R_S)-1-(p-tolylsulfinyl)-4-methoxy-3-pentene-2-one 

Relevant articles and documents

PANTETHEINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.

Iridium-catalyzed asymmetric hydrogenation of vinyl ethers

A carbene-oxazoline catalyst 1 proved to be an effective catalyst for reduction of an enol ether that the literature suggested could not be hydrogenated effectively by P,N-Ir catalysts. Thus, a series of ester and alcohol substrates were hydrogenated using catalyst 1. Good to excellent enantioselectivities and high conversions were obtained.

New insights into the reduction of β,δ-diketo-sulfoxides

New developments in the reduction of β,δ-diketo-sulfoxides, a reaction that affords important key intermediates for total synthesis, are described. We showed without ambiguity using NMR experiments, that the β-carbonyl group is totally enolised. This result is inconsistent with the previous hypothesis, which supposed the other tautomer (enolisation at the δ-position) as the major one. We propose a rationale to explain the side reactions occurring during the reduction of unprotected β,δ-diketo-sulfoxides and showed that judicious protection of the δ-carbonyl group gave all diastereoisomers of β-hydroxy-δ-ketosulfoxides.