22180-30-9Relevant articles and documents
A berberine of the preparation method of the key intermediate
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Paragraph 0023-0024; 0027-0028, (2018/05/16)
The invention discloses a preparation method of a key intermediate of berberine. The method comprises the following steps: enabling pepper benzyl chloride to react with malonic acid diester under the action of organic alkali, so as to obtain pepper diester benzylmalonate; carrying out decarboxylation on the pepper diester benzylmalonate under the catalysis of strong alkali; enabling pepper propionic acid to react with phosphorus pentachloride in an organic solvent, so as to obtain pepper propionyl chloride; enabling pepper propionyl chloride to react with ammonia gas or ammonia water in the organic solvent, so as to obtain pepper propanamide; and carrying out Hoffman rearrangement reaction on propanamide under the common action of sodium hypochlorite or chlorine gas or sodium hydroxide, so as to obtain the pepper ethylamine. According to the method disclosed by the invention, raw materials are available, the operation is simple, the reaction condition is mild, and industrial production can be achieved easily.
Sulfonic ester derivatives, process for preparing the same, and use thereof
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, (2008/06/13)
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An efficient enantioselective total synthesis of antitumor lignans: Synthesis of enantiomerically pure 4-hydroxyalkanenitriles via an enzymatic reaction
Itoh,Chika,Takagi,Nishiyama
, p. 5717 - 5723 (2007/10/02)
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