222025-81-2

Basic information

• Product Name: 2-nitro-1-(4-nitrophenyl)butan-1-ol
• Synonyms: 2-nitro-1-(4-nitrophenyl)butan-1-ol
• CAS NO: 222025-81-2
• Molecular Weight: 240.216
• Mol File: 222025-81-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-nitro-1-(4-nitrophenyl)butan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-1-(4-nitrophenyl)butan-1-ol(222025-81-2)
• EPA Substance Registry System: 2-nitro-1-(4-nitrophenyl)butan-1-ol(222025-81-2)

Safety Data

• Hazardous Substances Data: 222025-81-2(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 64-02-8 disodium ethylenediaminetetraacetic acid 
• 108-03-2 1-Nitropropane 
• 619-73-8 4-nitrobenzyl chloride 

Downstream Products

• 222026-11-1 4-ethyl-3-(4-nitro-phenyl)-1H-pyrrole-2-carboxylic acid tert-butyl ester 
• 49678-62-8 1-nitro-4-[(1E)-2-nitro-1-butenyl]benzene 

Relevant articles and documents

Enzyme-catalyzed Henry (nitroaldol) reaction

Transglutaminase was first used to catalyze Henry reactions of aliphatic, aromatic and hetero-aromatic aldehydes with nitroalkanes. The reactions were carried out at room temperature, and the corresponding nitro alcohols were obtained in yields up to 96%.

Polymer supported DMAP: An easily recyclable organocatalyst for highly atom-economical Henry reaction under solvent-free conditions

Polymer supported catalysts are regarded as a borderline class of catalysts, which retains the advantages of homogeneous catalysts while securing the ease of recovery by simple filtration and workup of heterogeneous systems. Additionally, such catalysts are less hygroscopic due to the long polymer backbone. Here we have demonstrated that a catalytic amount of polymer supported DMAP (10 mol%) can lead to excellent conversion of an equimolar mixture of aldehyde and nitroalkane exclusively into β-nitroalcohols via the Henry reaction. Unlike most of the commonly used catalysts, polymer supported DMAP can be recovered by simple filtration and reused several times, thereby reducing the operational cost. High synthetic efficiency, total atom economy, near quantitative yields, mild reaction conditions, operational simplicity, easy recovery and reusability of the catalyst, solvent-free reaction conditions and avoidance of traditional reaction workup make the protocol highly significant from Green and Sustainable Chemistry perspectives.

Size-dependent catalysis by DABCO-functionalized Zn-MOF with one-dimensional channels

Lewis basic DABCO-functionalized 3D-like metal-organic framework, Zn-MOF, catalyzes nitroaldol (Henry) reaction of 4-nitrobenzaldehyde with nitroalkanes in a size-dependent manner. Small nitroalkanes give rise to higher conversion than larger ones. This M