222036-26-2 Usage
Description
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is an organic compound that serves as a crucial intermediate in the synthesis of Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). 8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is characterized by its unique chemical structure, which includes a methylsulfanyl group and a thiazoloindole framework. Its role in the development of PKR inhibitors highlights its potential significance in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is used as an intermediate in the synthesis of PKR inhibitors for their potential therapeutic applications. As a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR), it has demonstrated effective inhibition of PKR function in vivo. This inhibition can lead to various beneficial effects, such as neuroprotection and cognitive enhancement, as observed in animal studies.
Used in Neuroprotective Applications:
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is used as a neuroprotective agent due to its role in the synthesis of PKR inhibitors. These inhibitors have shown to provide protection against neuronal damage and degeneration, which can be particularly useful in the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
Used in Nootropic Applications:
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is used as a nootropic agent, contributing to the development of PKR inhibitors with cognitive-enhancing properties. These inhibitors can potentially improve memory, learning, and overall cognitive function, making them valuable in the treatment of cognitive disorders and for enhancing cognitive performance in healthy individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 222036-26-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,0,3 and 6 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 222036-26:
(8*2)+(7*2)+(6*2)+(5*0)+(4*3)+(3*6)+(2*2)+(1*6)=82
82 % 10 = 2
So 222036-26-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2OS2/c1-14-9-7-5(12-10(9)13)2-3-6-8(7)15-4-11-6/h2-4,9H,1H3,(H,12,13)
222036-26-2Relevant articles and documents
3-(anilinomethylene) oxindoles
-
Page column 46-47, (2010/02/04)
The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis
Bramson,Holmes,Hunter,Lackey,Lovejoy,Luzzio,Montana,Rocque,Rusnak,Shewchuk,Veal,Corona,Walker,Kuyper,Davis,Dickerson,Edelstein,Frye,Gampe Jr.,Harris,Hassell
, p. 4339 - 4358 (2007/10/03)
Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently inhibit cyclin-dependent kinase 2 (CDK2). The initial lead compound was prepared as a homologue of the 3-benzylidene-1,3-dihydro-2H-indol-2-one class of kinase inhibitor. Crystallographic analysis of the lead compound bound to CDK2 provided the basis for analogue design. A semiautomated method of ligand docking was used to select compounds for synthesis, and a number of compounds with low nanomolar inhibitory activity versus CDK2 were identified. Enzyme binding determinants for several analogues were evaluated by X-ray crystallography. Compounds in this series inhibited CDK2 with a potency ～10-fold greater than that for CDK1. Members of this class of inhibitor cause an arrest of the cell cycle and have shown potential utility in the prevention of chemotherapy-induced alopecia.
