2221-09-2

Basic information

• Product Name: 2-phenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione
• Synonyms: 1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione, tetrahydro-2-phenyl-
• CAS NO: 2221-09-2
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.2359
• Mol File: 2221-09-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331.2°C at 760 mmHg
• Flash Point: 145.7°C
• Density: 1.35g/cm³
• Vapor Pressure: 0.000158mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 2-phenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione(2221-09-2)
• EPA Substance Registry System: 2-phenyltetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dione(2221-09-2)

Safety Data

• Hazardous Substances Data: 2221-09-2(Hazardous Substances Data)

Upstream product

• 438238-39-2 5-(3-chloro-propyl)-3-phenyl-imidazolidine-2,4-dione 
• 141-52-6 sodium ethanolate 
• 103-71-9 phenyl isocyanate 
• 147-85-3 L-proline 
• 533-88-0 2-amino-5-hydroxyvaleric acid 
• 860256-02-6 5-hydroxy-2-(N'-phenyl-ureido)-valeric acid 

Relevant articles and documents

Microwave-assisted solid-phase synthesis of hydantoin derivatives

A microwave-assisted synthesis of 3,5- and 1,3,5-substituted hydantoins starting from various resins for solid-phase combinatorial chemistry has been developed. The hydantoins were synthesized from pre-loaded resins with amino acids via treatment with isocyanate or phenylisocyanate and subsequent intramolecular cyclization. Both reactions were performed under microwave irradiation. We studied the cyclative cleavage leading to hydantoin compounds dependent on the nature of the amino acid and the nucleofuge properties of the resin.

Hydantoin derivative compounds, pharmace utical compositions, and methods of using same

The present invention relates generally to novel hydantoin derivative compounds, pharmaceutical compositions containing such compounds, and methods for their use in preventing and/or treating neurological disorders, including physically damaged nerves and neurodegenerative diseases; for treating alopecia and promoting hair growth; for treating vision disorders and/or improving vision; for treating memory impairment and/or enhancing memory performance; and for treating sensorineural hearing loss by administering such compounds.