22245-92-7

Basic information

• Product Name: 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
• Synonyms: 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one;7-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE;2H-1-Benzazepin-2-one, 7-aMino-1,3,4,5-tetrahydro-;7-aMino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one;7-Aminodihydrohomocarbostyril;7-amino-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one
• CAS NO: 22245-92-7
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Mol File: 22245-92-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 426.313°C at 760 mmHg
• Flash Point: 211.627°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.76±0.20(Predicted)
• CAS DataBase Reference: 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(22245-92-7)
• EPA Substance Registry System: 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(22245-92-7)

Safety Data

• Hazardous Substances Data: 22245-92-7(Hazardous Substances Data)

Usage

General Description

7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one, also known as o-phenylendiamine, is a chemical compound with the molecular formula C16H19N3O. It is a bicyclic heterocycle and a derivative of 1,3,4,5-tetrahydro-1-benzazepin-2-one. 7-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one is commonly used in medicinal chemistry as a building block for various pharmaceuticals, including antipsychotic and antidepressant drugs. It exhibits a wide range of biological activities and has the potential for being developed as a therapeutic agent for the treatment of various neurological disorders. Additionally, it is also used as a precursor in the synthesis of other organic compounds, making it an important intermediate in the pharmaceutical industry.

InChI:InChI=1/C10H12N2O/c11-8-4-5-9-7(6-8)2-1-3-10(13)12-9/h4-6H,1-3,11H2,(H,12,13)

Upstream product

• 22246-45-3 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 3349-64-2 1-tetralone oxime 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 939043-29-5 (1E)-6-Amino-3,4-dihydro-1(2H)-naphthalenone oxime 
• 1022954-85-3 6-aminotetralin-1-one oxime 
• 3470-53-9 6-amino-1-tetralone 

Downstream Products

• 22344-77-0 7-Chlor-1,3,4,5-tetrahydro-2H-benzazepin-2-on 
• 53841-99-9 7-Brom-1,3,4,5-tetrahydro-2H-benzazepin-2-on 
• 104479-35-8 4-(2,5-Diamino-4-nitro-phenyl)-butyric acid methyl ester 
• 1022946-74-2 2-[5-chloro-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-8-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide 

Relevant articles and documents

NOVEL IMIDAZO-PYRAZINE DERIVATIVES

The invention provides novel imidazo-pyrazine derivatives having the general formula (I), and pharmaceutically acceptable salts thereof, wherein X, m, n, and R1to R3 are as described herein: formula (I). Further provided are pharmace

3. 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivative and its preparation method and application. In particular, the invention relates to the formula (I) structure of 3, 4 - diphenyl - 4H - 1, 2, 4 - triazole derivatives, its stereoisomers or its pharmaceutically acceptable salt, formula (I) in the definition of each substituent is as defined in the specification. These structure of novel compound with heat shock protein HSP90 inhibitory activity, can be used for treating cancer, neurodegenerative diseases, inflammatory diseases, autoimmune diseases, ischemic brain injury and the like, it has broad application prospects. (by machine translation)

1-Benzazepine-3-Sulfonylamino-2-Pyrroridones as Factor Xa Inhibitors

The invention relates to chemical entities of formula (I): and/or pharmaceutically acceptable derivative(s) thereof. The invention also relates to processes for the preparation of compounds of formula (I), pharmaceutical compositions containing compounds