22282-70-8

Basic information

• Product Name: 2-Fluoro-4-iodopyridine
• Synonyms: 4-Iodo-2-fluoropyridine;2-Fluoro-4-iodopyridine AldrichCPR;2-FLUORO-4-IODOPYRIDINE
• CAS NO: 22282-70-8
• Molecular Formula: C₅H₃FIN
• Molecular Weight: 222.99
• Product Categories: pharmacetical;Pyridine series;Heterocycle;Pyridines;Boronic Acid;Propidium heterocyclic series;NULL;Fluorine series;alkyl Iodine|alkyl Fluorine;Fluorin-contained pyridine series;Pyridine
• Mol File: 22282-70-8.mol
• Article Data: 15

Chemical Properties

• Melting Point: 57 °C
• Boiling Point: 223 °C at 760 mmHg
• Flash Point: 88.6 °C
• Appearance: Salmon-coloured solid
• Density: 2.046 g/cm³
• Vapor Pressure: 0.147mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Refrigerated.
• Solubility: soluble in Methanol
• PKA: -1.81±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Fluoro-4-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-iodopyridine(22282-70-8)
• EPA Substance Registry System: 2-Fluoro-4-iodopyridine(22282-70-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 22-26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22282-70-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H3FIN/c6-5-3-4(7)1-2-8-5/h1-3H

Upstream product

• 113975-22-7 2-fluoro-3-iodopyridine 
• 372-48-5 2-fluoropyridine 
• 168428-74-8 2-fluoro-4-iodo-3-pyridyllithium 
• 128071-98-7 4-bromo-2-fluoropyridine 

Downstream Products

• 361147-25-3 2-chloro-4-(2-fluoropyridin-4-yl)pyrimidine 
• 552331-57-4 2-fluoro-4-vinylpyridine 
• 883199-21-1 N-(3-chlorophenyl)-4-iodo-2-pyridinamine 
• 883199-23-3 N-(3-chlorophenyl)-N-(2'-fluoro-[4,4']-bipyridinyl-2-yl)amine 
• 883199-18-6 N-[3-(2-fluoropyridin-4-yl)-phenyl]-carbamic acid 1,1-dimethylethyl ether 
• 883199-17-5 3-(2-fluoropyridin-4-yl)-phenylamine 
• 924311-96-6 2-fluoro-4-[(E)-2-(4-fluorophenyl)vinyl]pyridine 
• 896155-81-0 2-(benzyloxy)-4-iodopyridine 
• 950918-49-7 (2-fluoro-pyridin-4-yl)-(2-methoxy-phenyl)-methanol 
• 950918-50-0 (2-fluoro-pyridin-4-yl)-m-tolyl-methanol 
• 950918-48-6 (2-fluoro-pyridin-4-yl)-phenyl-methanol 
• 950918-54-4 (2-aminoo-pyridin-4-yl)-phenyl-methanone 
• 950918-55-5 (2-amino-pyridin-4-yl)-(2-methoxy-phenyl)-methanone 
• 950918-56-6 (2-amino-pyridin-4-yl)-m-tolyl-methanone 

Relevant articles and documents

NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.

ANTIVIRAL COMPOUNDS

The present invention relates to a compound of formula: (I) or a pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing a viral infection such as HIV using the same.

INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS

The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved