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222991-29-9

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222991-29-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 222991-29-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,2,9,9 and 1 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 222991-29:
(8*2)+(7*2)+(6*2)+(5*9)+(4*9)+(3*1)+(2*2)+(1*9)=139
139 % 10 = 9
So 222991-29-9 is a valid CAS Registry Number.

222991-29-9Relevant articles and documents

Highly chemoselective trichloroacetimidate-mediated alkylation of ascomycin: A convergent, practical synthesis of the immunosuppressant L- 733,725

Song, Zhiguo,DeMarco, Anthony,Zhao, Mangzhu,Corley, Edward G.,Thompson, Andrew S.,McNamara, James,Li, Yulan,Rieger, Dale,Sohar, Paul,Mathre, David J.,Tschaen, David M.,Reamer, Robert A.,Huntington, Martha F.,Ho, Guo-Jie,Tsay, Fuh-Rong,Emerson, Khateeta,Shuman, Richard,Grabowski, Edward J. J.,Reider, Paul J.

, p. 1859 - 1867 (2007/10/03)

L-733,725, a new immunosuppressant drug candidate, was prepared by a highly chemoselective alkylation of the macrolide ascomycin at the C32 hydroxy position with the imidazolyl trichloroacetimidate 16. The trichloroacetimidate-activated side chain 16 was prepared by an efficient fourstep sequence in 42% overall yield. The high chemoselectivity in the alkylation of the C32 hydroxy group of the unprotected ascomycin was the result of the synergetic effects of the electron-donating protecting group on the imidazole 16, the polar, moderately basic solvent, and the strong acid catalyst. N,N-Dimethylpivalamide mixed with acetonitrile was found to be the best solvent and trifluromethanesulfonic acid the best catalyst. This synthesis coupled with a resin column purification of L-733,725 followed by crystallization of its tartrate salt has been used to make multikilogram quantities of the bulk drug with consistent and high purity.

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