22328-43-4

Basic information

• Product Name: Benzoyl chloride, 2,5-dimethyl- (6CI,7CI,8CI,9CI)
• Synonyms: Benzoyl chloride, 2,5-dimethyl- (6CI,7CI,8CI,9CI);2,5-Dimethylbenzoylchloride;BENZOYL CHLORIDE,2,5-DIMETHYL-
• CAS NO: 22328-43-4
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62016
• Product Categories: ACIDHALIDE
• Mol File: 22328-43-4.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 239.3±9.0 °C(Predicted)
• Appearance: /
• Density: 1.136±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoyl chloride, 2,5-dimethyl- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2,5-dimethyl- (6CI,7CI,8CI,9CI)(22328-43-4)
• EPA Substance Registry System: Benzoyl chloride, 2,5-dimethyl- (6CI,7CI,8CI,9CI)(22328-43-4)

Safety Data

• Hazardous Substances Data: 22328-43-4(Hazardous Substances Data)

Upstream product

• 610-72-0 2,5-dimethylbenzoic acid 
• 79-37-8 oxalyl dichloride 
• 106-42-3 para-xylene 
• 2142-73-6 1-(2,5-dimethylphenyl)-1-ethanone 
• 553-94-6 4-bromo-m-xylene 
• 95-78-3 2,5-Dimethylaniline 

Downstream Products

• 115209-69-3 (2,5-dimethyl-phenyl)-pyren-1-yl ketone 
• 35019-05-7 2,2',5,5'-tetramethyldiphenylmethanone 
• 867131-83-7 (2-ethyl-[1]naphthyl)-(2,5-dimethyl-phenyl)-ketone 
• 6332-05-4 1,3,5,7-Tetramethyl-anthrachinon 
• 93151-42-9 2,5-dimethyl-benzoic acid-(2-diethylamino-ethylamide) 
• 35019-06-8 2,4,6,2',5'-pentamethyl-benzophenone 
• 58358-37-5 2,5-dimethylphenylacetic acid ethyl ester 
• 47776-92-1 C₃₀H₃₃NO₅ 
• 57487-57-7 C₂₄H₂₁Cl₂N₅O 
• 892020-32-5 N'-(2,5-Dimethyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester 
• 145105-08-4 (2,5-Dimethyl-phenyl)-((S)-2-methoxymethyl-pyrrolidin-1-yl)-methanone 
• 112575-57-2 N-[3-(2-pyridyl)isoquinolin-1-yl]-2,5-dimethylbenzamide 
• 13152-96-0 (2,5-dimethylphenyl)(p-tolyl)methanone 
• 179096-55-0 N-but-3-enyl-2,5-dimethyl-N-(1,1-dimethylbenzyl)benzamide 

Relevant articles and documents

Synthesis and in vitro antimicrobial activity of new 2-[p-substituted-benzyl]-5-[substituted-carbonylamino]benzoxazoles

Some new 2-(benzyl/p-chlorobenzyl)-5-[(substituted-thienyl/phenyl/phenylthiomethyl/benzyl)carbonylamino]benzoxazole derivatives have been synthesized by reacting 5-amino-2-(benzyl/p-chlorobenzyl)benzoxazoles with appropriate carboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR, 1H NMR and MASS spectral data. In vitro antimicrobial activities of the compounds were investigated using twofold serial dilution technique against different two Gram-positive, two Gram-negative bacteria and three Candida spp. in comparison with standard drugs. Microbiological results indicated that the newly synthesized 2-(benzyl/p-chlorobenzyl)-5-[(substituted-thienyl/phenyl/phenylthiomethyl/benzyl)carbonylamino]benzoxazole derivatives (3-12) possessed a broad spectrum of activity having MIC values of 6.25-100 μg/ml against the tested microorganisms. Especially, with an MIC value of 6.25 μg/ml, 2-(p-chlorophenyl)-5-[(2,5-dimethylphenyl)carbonylamino]benzoxazole 4 displayed the same activity against Candida albicans as the standard drug clotrimazole.

N-Heterocyclic Carbene Catalyzed Photoenolization/Diels–Alder Reaction of Acid Fluorides

The combination of light activation and N-heterocyclic carbene (NHC) organocatalysis has enabled the use of acid fluorides as substrates in a UVA-light-mediated photochemical transformation previously observed only with aromatic aldehydes and ketones. Stoichiometric studies and TD-DFT calculations support a mechanism involving the photoactivation of an ortho-toluoyl azolium intermediate, which exhibits “ketone-like” photochemical reactivity under UVA irradiation. Using this photo-NHC catalysis approach, a novel photoenolization/Diels–Alder (PEDA) process was developed that leads to diverse isochroman-1-one derivatives.

C?O Activation by a Rhodium Bis(N-Heterocyclic Carbene) Catalyst: Aryl Carbamates as Arylating Reagents in Directed C?H Arylation

Despite recent progress in the catalytic transformation of inert phenol derivatives as alternatives to aryl halides and triflates, attempts at the cross-coupling of inert phenol derivatives with the C?H bonds of arenes have met with limited success. Herein, we report the rhodium-catalyzed cross-coupling of aryl carbamates with arenes bearing a convertible directing group. The key to success is the use of an in situ generated rhodium bis(N-heterocyclic carbene) species as the catalyst, which can promote activation of the inert C(sp2)?O bond in aryl carbamates.