22333-70-6

Basic information

• Product Name: Dibenzoyltartaric acid
• Synonyms: dibenzoyltartaric acid;2,3-Bis(benzoyloxy)-butanedioic acid;Tartaric acid dibenzoate;Butanedioic acid,2,3-bis(benzoyloxy)-, (2R,3R)-rel-
• CAS NO: 22333-70-6
• Molecular Formula: C₁₈H₁₄O₈
• Molecular Weight: 358.3
• Mol File: 22333-70-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 606.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.438
• PKA: 1.85±0.25(Predicted)
• CAS DataBase Reference: Dibenzoyltartaric acid(CAS DataBase Reference)
• NIST Chemistry Reference: Dibenzoyltartaric acid(22333-70-6)
• EPA Substance Registry System: Dibenzoyltartaric acid(22333-70-6)

Safety Data

• Hazardous Substances Data: 22333-70-6(Hazardous Substances Data)

Upstream product

• 87-69-4 L-Tartaric acid 
• 98-88-4 benzoyl chloride 
• 17637-11-5 (+/-)-O,O'-dibenzoyltartaric anhydride 

Downstream Products

• 39010-59-8 (2R,3R)-2,3-Bis-benzoyloxy-succinic acid; compound with (R)-1-dimethylamino-butan-2-ol 
• 93246-15-2 (2R,3R)-2,3-Bis-benzoyloxy-succinic acid; compound with (S)-1-dimethylamino-butan-2-ol 
• 17026-42-5 O,O'-dibenzoyl-D-tartaric acid 
• 2743-38-6 O,O'-dibenzoyl-L-tartaric acid 
• 1012065-72-3 (S)-2-amino-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline-3-carboxylic acid ethyl ester, (S,S)-2,3-bisbenzoyloxysuccinic acid salt 
• 1012065-63-2 (S)-2-amino-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline-3-carboxylic acid methyl ester, (S),(S)-2,3-bisbenzoyloxy-succinic acid 
• 1012065-66-5 (S)-2-amino-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline-3-carboxylic acid isopropyl ester, (S),(S)-2,3-bisbenzoyloxy-succinic acid 

Relevant articles and documents

Process for the continuous production of basic cyclic optically active alpha - amino acids

PCT No. PCT/EP96/04073 Sec. 371 Date Mar. 24, 1998 Sec. 102(e) Date Mar. 24, 1998 PCT Filed Sep. 18, 1996 PCT Pub. No. WO97/12881 PCT Pub. Date Apr. 10, 1997The invention pertains to a process for the continuous production of basic cyclic optically active alpha -amino acids of general formula (I) by continuous racemate splitting via diastereomeric salt pairs with re-racemisation of the residual amino acid or amino acid derivative in the mother liquid with the aid of an optically active acid.

Simple resolution of O,O'-dibenzoyltartaric acid by preferential crystallization of its calcium salt-methoxyethanol complex

The enantiomers of the title compound can be obtained in a simple two-step crystallization procedure starting from the racemate. The compound 2 of the calcium O,O'-dibenzoyl-tartrate formed with two molecules of 2-methoxyethanol exists as a conglomerate, making a simple enantioseparation possible.