223770-00-1Relevant articles and documents
1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors
Rewinkel,Lucas,Van Galen,Noach,Van Dinther,Rood,Jenneboer,Van Boeckel
, p. 685 - 690 (1999)
Replacement of the highly basic benzamidine moiety of NAPAP by the moderately basic 1-aminoisoquinoline moiety resulted in thrombin inhibitors with improved selectivity towards trypsin and enhanced Caco-2 cell permeability.