2244-85-1

Basic information

• Product Name: 4-hexyl-1,3-dioxane
• Synonyms: 4-hexyl-1,3-dioxane;1,3-Dioxane, 4-hexyl-;Einecs 218-830-9
• CAS NO: 2244-85-1
• Molecular Formula: C₁₀H₂₀O₂
• Molecular Weight: 172.2646
• EINECS: 218-830-9
• Mol File: 2244-85-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 214.3°Cat760mmHg
• Flash Point: 78.7°C
• Appearance: /
• Density: 0.896g/cm³
• Vapor Pressure: 0.229mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: 4-hexyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hexyl-1,3-dioxane(2244-85-1)
• EPA Substance Registry System: 4-hexyl-1,3-dioxane(2244-85-1)

Safety Data

• Hazardous Substances Data: 2244-85-1(Hazardous Substances Data)

Usage

General Description

4-hexyl-1,3-dioxane is a chemical compound with the molecular formula C10H20O2. It is a colorless liquid with a faint, sweet odor, and is used mainly as a solvent in various industrial applications. It is insoluble in water but soluble in organic solvents, and is considered to be moderately volatile. 4-hexyl-1,3-dioxane is primarily used in the production of adhesives, coatings, and cleaning products, and has also been studied for its potential use in pharmaceuticals and as a fragrance ingredient. While it has low acute toxicity, long-term exposure to 4-hexyl-1,3-dioxane may cause irritation to the skin, eyes, and respiratory system, and it may have harmful effects on aquatic organisms.

InChI:InChI=1/C10H20O2/c1-2-3-4-5-6-10-7-8-11-9-12-10/h10H,2-9H2,1H3

Upstream product

• 50-00-0 formaldehyd 
• 111-66-0 oct-1-ene 

Relevant articles and documents

ZnAlMCM-41: a very ecofriendly and reusable solid acid catalyst for the highly selective synthesis of 1,3-dioxanes by the Prins cyclization of olefins

The Prins cyclization of styrene (SE) with paraformaldehyde (PFCHO) was conducted with mesoporous ZnAlMCM-41 catalysts for the synthesis of 4-phenyl-1,3-dioxane (4-PDO) using a liquid phase heterogeneous catalytic method. For a comparison study, the Prins cyclization reaction was also conducted over different nanoporous catalysts,e.g.mesoporous solid acid catalysts, AlMCM-41(21) and ZnMCM-41(21), and microporous catalysts, USY, Hβ, HZSM-5, and H-mordenite. The recyclable mesoporous ZnAlMCM-41 catalysts were reused in this reaction to evaluate their catalytic stabilities. Since ZnAlMCM-41(75) has higher catalytic activity than other solid acid catalysts, washed ZnAlMCM-41(75)/W-ZnAlMCM-41(75) was prepared using an efficient chemical treatment method and used with various reaction parameters to find an optimal parameter for the highly selective synthesis of 4-PDO. W-ZnAlMCM-41(75) was also used in the Prins cyclization of olefins with PFCHO and formalin (FN, 37% aqueous solution of formaldehyde (FCHO)) under different reaction conditions to obtain 1,3-dioxanes, which are widely used as solvents or intermediates in organic synthesis. Based on the nature of catalysts used under different reaction conditions, a reasonable plausible reaction mechanism for the Prins cyclization of SE with PFCHO is proposed. Notably, it can be seen from the catalytic results of all catalysts that the W-ZnAlMCM-41(75) catalyst has higher 4-PDO selectivity with exceptional catalytic activity than other microporous and mesoporous catalysts.

Synthesis of 1,3-dioxanes catalyzed by TsOH-SiO2 under solvent-free conditions

Silica-supported p-toluene sulfonic acid is found to be an excellent catalyst for the Prins reaction to produce 1,3-dioxanes in good yields from olefins and aliphatic aldehydes in dichloromethane at room temperature and solventless microwave irradiation within a short reaction time. Copyright Taylor & Francis Group, LLC.