22454-57-5

Basic information

• Product Name: Benzoic acid,2-[1-(4-methoxyphenyl)ethylidene]hydrazide
• Synonyms: Benzoicacid, (p-methoxy-a-methylbenzylidene)hydrazide(8CI); Benzoic acid, [1-(4-methoxyphenyl)ethylidene]hydrazide (9CI); NSC 166733
• CAS NO: 22454-57-5
• Molecular Formula: C16H16 N2 O2
• Molecular Weight: 268.315
• Mol File: 22454-57-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.09g/cm³
• CAS DataBase Reference: Benzoic acid,2-[1-(4-methoxyphenyl)ethylidene]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid,2-[1-(4-methoxyphenyl)ethylidene]hydrazide(22454-57-5)
• EPA Substance Registry System: Benzoic acid,2-[1-(4-methoxyphenyl)ethylidene]hydrazide(22454-57-5)

Safety Data

• Hazardous Substances Data: 22454-57-5(Hazardous Substances Data)

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 768-60-5 4-methoxyphenylacetylen 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 6298-96-0 1(R)-(4-methoxyphenyl)-ethylamine 
• 6298-96-0 (S)-1-(4-methoxyphenyl)ethylamine 
• 142068-36-8 (S)-1-p-methoxyphenyl-1-(2-benzoylhydrazino)ethane 
• 142068-36-8 (R)-1-p-methoxyphenyl-1-(2-benzoylhydrazino)ethane 
• 99478-31-6 1-benzoyl-5-(2-hydroxyphenyl)-3-(4-methoxyphenyl)pyrazole 
• 99466-19-0 1-benzoyl-3-(4-methoxyphenyl)-5-phenacylpyrazole 

Relevant articles and documents

Copper catalyzed cyanomethylation reaction of 4-thiazolidinone

An effective copper catalyzed Cross Dehydrogenative Coupling (CDC) reaction of 4-thiazolidinones with acetonitrile has been developed. The described strategy undergoes radical pathway by employing copper, oxidant and easily available acetonitrile as a cya

Copper(II)-faciliated synthesis of substituted thioethers and 5-substituted 1H-tetrazoles: Experimental and theoretical studies

Benzoylhydrazine based Schiff base-ligated two new copper(II) complexes, [Cu(L1)2] (1) and [Cu(L2)2] (2) were synthesized by the reaction of Cu(CH3COO)2·H2O with respective Schiff base ligand 1-[(4-nitrophenyl)ethylidene] benzohydrazide (HL1) or 1-[(4-methoxyphenyl)ethylidene] benzohydrazide (HL2). Both complexes were isolated as greenish solid and fully characterized by elemental analysis, FT-IR, EPR, thermo-gravimetric (TG) analysis and Cyclic Voltammetry. The molecular structures of both complexes have also been determined by single crystal X-ray crystallography, which confirmed the coordination of Schiff base ligands through N, O donor atoms and distorted square planar geometry around the Cu(II) ion. Both complexes were found to be good homogeneous catalysts for the synthesis of a wide range of substituted thioethers and 5-substituted 1H-tetrazoles in 92% and 93% yield, respectively, at a low catalyst loading (0.5 mol%). The bond angles and distances, as discerned from the DFT calculations, commusurated with the experimental findings. The energy difference between the HOMO and the LUMO, calculated from DFT studies, was found to be 5.645 eV and 6.459 eV for complex 1 and complex 2, respectively. These results are in harmony with the observed higher catalytic activity of complex 1.

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.