22459-83-2

Basic information

• Product Name: N-(3-bromo-4-chlorophenyl)acetamide
• Synonyms: N-(3-bromo-4-chlorophenyl)acetamide
• CAS NO: 22459-83-2
• Molecular Weight: 248.507
• Mol File: 22459-83-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(3-bromo-4-chlorophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-bromo-4-chlorophenyl)acetamide(22459-83-2)
• EPA Substance Registry System: N-(3-bromo-4-chlorophenyl)acetamide(22459-83-2)

Safety Data

• Hazardous Substances Data: 22459-83-2(Hazardous Substances Data)

Upstream product

• 621-38-5 3-bromoacetanilide 
• 823-54-1 3-bromo-4-chloroaniline 
• 75-36-5 acetyl chloride 
• 591-19-5 m-Bromoaniline 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 103-84-4 Acetanilid 
• 7647-01-0 hydrogenchloride 
• 29551-87-9 acetic acid-(3-bromo-N-chloro-anilide) 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 90050-43-4 Oxim des 3-Brom-4-chlor-acetophenons 

Downstream Products

• 823-54-1 3-bromo-4-chloroaniline 

Relevant articles and documents

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

A Visible Light-Mediated Regioselective Halogenation of Anilides and Quinolines by Using a Heterogeneous Cu-MnO Catalyst

A simple and practical heterogeneous Cu-MnO catalyzed regioselective halogenation of anilides and quinolines under irradiation with household 40 W incandescent lamp was developed. This method uses a recyclable Cu-MnO catalyst, acetonitrile as an industrially friendly solvent, and economic N-halo succinimides as a halogenating source. The reaction is scalable and well tolerated with a broad range of functional groups.

Regioselective catalytic halogenation of aromatic substrates

Regioselective chlorination and bromination of some aromatic substances have been carried out using KCl and KBr in presence of sodium perborate as an oxidant and sodium metavanadate, sodium tungstate, ammonium metavanadate and ammonium molybdate as efficient catalysts. This environmentally friendly catalytic halogenation method gave good yields of products under mild conditions.