22479-40-9

Basic information

• Product Name: 1,2-bis(bromomethyl)-3-chlorobenzene
• Synonyms: 1,2-bis(bromomethyl)-3-chlorobenzene
• CAS NO: 22479-40-9
• Molecular Weight: 298.405
• Mol File: 22479-40-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-bis(bromomethyl)-3-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-bis(bromomethyl)-3-chlorobenzene(22479-40-9)
• EPA Substance Registry System: 1,2-bis(bromomethyl)-3-chlorobenzene(22479-40-9)

Safety Data

• Hazardous Substances Data: 22479-40-9(Hazardous Substances Data)

Usage

Chemical structure

1,2-bis(bromomethyl)-3-chlorobenzene consists of a benzene ring with two bromomethyl groups and a single chloro group attached.

Building block

It is commonly used as a building block in the synthesis of various organic compounds, such as pharmaceuticals and agrochemicals.

Reactivity

The bromomethyl groups are reactive and can participate in different chemical reactions, such as nucleophilic substitution and cross-coupling reactions.

Flammability

1,2-bis(bromomethyl)-3-chlorobenzene is flammable and should be handled with caution.

Safety concerns

Exposure to high temperatures or flames can result in the release of toxic gases.

Safety protocols

It is important to follow safety protocols when handling and storing 1,2-bis(bromomethyl)-3-chlorobenzene to prevent any potential hazards.

Upstream product

• 110706-48-4 3-chloro-1,2-di-(hydroxymethyl)benzene 
• 7789-60-8 phosphorus tribromide 
• 608-23-1 3-chloro-o-xylene 

Downstream Products

• 1616788-03-4 4-chloro-2-(3-phenylprop-2-yn-1-yl)isoindoline 
• 22479-39-6 2,2'-(3-chloro-1,2-phenylene)diacetonitrile 
• 22482-74-2 2-carboxymethyl-3-chlorobenzoic acid 

Relevant articles and documents

Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PLpro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PLpro are valuable starting points for the development of new pan-coronaviral inhibitors.

Benzazepine Compound

[Problem] Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and

Isoindolinyl derivatives

Esters of lower alkanoic acids substituted at the α-position with isoindoline or tetrahydroisoquinoline, and intermediates therefor, useful as pesticides.