22488-76-2Relevant articles and documents
Synthesis of E-α,β-unsaturated ketones with complete stereoselectivity via sequential aldol-type/elimination reactions promoted by samarium diiodide or chromium dichloride
Concellón, José M.,Rodríguez-Solla, Humberto,Concellón, Carmen,Díaz, Pamela
, p. 837 - 840 (2007/10/03)
E-α,β-Unsaturated ketones can be obtained with complete E-selectivity by a sequential reaction of dichloroketones with a variety of aldehydes. This transformation was promoted by SmI2, SmI2 in the presence of FeCl3 or CrCl2. The best results were obtained when CrCl2 was used as the metallating agent. A mechanism based on a successive aldol-type reaction and a β-elimination is proposed to explain these results. Georg Thieme Verlag Stuttgart.