225122-62-3

Basic information

• Product Name: methyl 3-(2-iodoethoxy)benzoate
• Synonyms: methyl 3-(2-iodoethoxy)benzoate
• CAS NO: 225122-62-3
• Molecular Weight: 306.1
• Mol File: 225122-62-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 3-(2-iodoethoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(2-iodoethoxy)benzoate(225122-62-3)
• EPA Substance Registry System: methyl 3-(2-iodoethoxy)benzoate(225122-62-3)

Safety Data

• Hazardous Substances Data: 225122-62-3(Hazardous Substances Data)

Upstream product

• 59516-96-0 1-Bromo-2-(3'-carbomethoxyphenoxy)ethane 
• 19438-10-9 methyl 3-hydroxybenzoate 

Downstream Products

• 225122-64-5 2-amino-4-[3-(methoxycarbonyl)-phenoxy]-butyronitrile 
• 225121-08-4 N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide 
• 225122-63-4 2-(diphenylmethyleneamino)-4-[(3-methoxycarbonyl)-phenoxy]-butyronitrile 

Relevant articles and documents

Dipeptide nitriles

N-terminal substituted dipeptide nitriles as defined are useful as inhibitors of cysteine cathepsins, e.g. cathepsins B, K, L and S, and can be used for the treatment of cysteine cathepsin dependent diseases and conditions, including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis, tumors (especially tumor invasion and tumor metastasis), coronary disease, atherosclerosis (including atherosclerotic plaque rupture and destabilization). Particular dipeptide nitriles are compounds of formula I, or physiologically-acceptable and -cleavable esters or a salts thereof wherein: the symbols are as defined. In particular it has been found that by appropriate choice of groups R, R2, R3, R4, R5, X1, Y and L, the relative selectivity of the compounds as inhibitors of the various cysteine cathepsin types, e.g. cathepsins B, K, L and S may be altered, e.g. to obtain inhibitors which selectively inhibit a particular cathepsin type or combination of cathepsin types.