225780-82-5

Basic information

• Product Name: Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-OtBu
• Synonyms: Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-OtBu
• CAS NO: 225780-82-5
• Molecular Weight: 640.818
• Mol File: 225780-82-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-OtBu(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-OtBu(225780-82-5)
• EPA Substance Registry System: Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-OtBu(225780-82-5)

Safety Data

• Hazardous Substances Data: 225780-82-5(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 225780-81-4 Cbz-N-(cyclohexyl)-Gly-D-Ala-L-leu-OtBu 
• 225780-96-1 Cbz-N-(cyclohexyl)-glycine ethyl ester 
• 96540-71-5 N^α-cyclohexyl-Gly(N^α-Cbz)-OH 
• 78031-82-0 D-Ala-L-Leu-O-tBu 
• 78031-81-9 N-Cbz-(D)-Ala-(L)-Leu-O-tBu 
• 55227-00-4 α-Methyl (2R)-N-(tert-butoxycarbonyl)glutamate ester 

Downstream Products

• 225780-83-6 Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-OH 
• 225780-98-3 Boc-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala-OtBu 
• 225781-04-4 cyclo 
• 225781-01-1 Boc-Adda-D-iso-Glu(OMe)-N-(cyclohexyl)-Gly-D-Ala-L-Leu-D-β-Me-iso-Asp(OMe)-L-Ala-OH 

Relevant articles and documents

The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: Rational modifications imparting PP1 selectivity

Based on the results from previously reported molecular modeling analyses of the interactions between the inhibitor microcystin and the serine-threonine protein phosphatases 1 and 2A, we have designed analogues of microcystin LA with structural modifications intended to impart PP1 selectivity. The synthesis of several first generation analogues followed by inhibition assays revealed that all three are PP1-selective, as predicted. Although the observed selectivities are modest, one of the designed analogues is more selective for PP1 than any known small molecule inhibitor. Copyright (C) 1999 Elsevier Science Ltd.