22614-72-8

Basic information

• Product Name: 7-Chloro-2-hydroxyquinoline
• Synonyms: 7-CHLOROQUINOLIN-2(1H)-ONE;7-CHLORO-2-QUINOLONE;7-CHLORO-2-HYDROXYQUINOLINE;7-Chloro-1H-quinolin-2-one;7-CHLORO-2-HYDROXYQUINOLINE, 98+%
• CAS NO: 22614-72-8
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.6
• EINECS: 1308068-626-2
• Mol File: 22614-72-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 296-297 °C
• Boiling Point: 386.516 °C at 760 mmHg
• Flash Point: 187.558 °C
• Appearance: /
• Density: 1.412 g/cm³
• Vapor Pressure: 2.05E-05mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.91±0.70(Predicted)
• CAS DataBase Reference: 7-Chloro-2-hydroxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-2-hydroxyquinoline(22614-72-8)
• EPA Substance Registry System: 7-Chloro-2-hydroxyquinoline(22614-72-8)

Safety Data

• Hazardous Substances Data: 22614-72-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1322, 1946 DOI: 10.1021/ja01211a066

InChI:InChI=1/C9H6ClNO/c10-7-3-1-6-2-4-9(12)11-8(6)5-7/h1-5H,(H,11,12)

Upstream product

• 156820-88-1 4,7-dichloro-quinolin-2-ol 
• 445041-60-1 (E)-N-(3-chlorophenyl)-3-ethoxypropenamide 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 150869-42-4 methyl trans-4-chloro-2-aminocinnamate 
• 150869-43-5 (E)-3-[4-Chloro-2-(2-nitro-acetylamino)-phenyl]-acrylic acid methyl ester 
• 150869-41-3 methyl (E)-3-(4-chloro-2-nitrophenyl)acrylate 

Downstream Products

• 613-77-4 2,7-dichloroquinoline 
• 143816-80-2 7-chloro-2-<(3-hydroxyphenyl)thio>quinoline 
• 143816-79-9 7-chloro-2-<(3-methoxyphenyl)thio>quinoline 
• 143816-63-1 2-[3-(7-Chloro-quinolin-2-ylsulfanyl)-phenoxy]-propionic acid 
• 143816-81-3 methyl D,L-2-<3-<(7-chloroquinolinyl)thio>phenoxy>propanoate 
• 5443-04-9 N⁴,N⁴-diethyl-N¹-(7-chloro-[2]quinolyl)-1-methyl-butanediyldiamine 
• 1219130-54-7 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-quinolin-2-one 

Relevant articles and documents

3-(1H-PYRAZOL-4-YL)PYRIDINE ALLOSTERIC MODULATORS OF M4 MUSCARINIC ACETYLCHOLINE RECEPTOR

Provided are cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor, compositions comprising said compounds, and uses of said compounds in the treatment or prevention of diseases in which M4 muscarinic acetylcholine receptors are involved, especially neurological and psychiatric disorders and diseases.

3-nitro-3,4-dihydro-2(1H)-quinolones - Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors

-