22618-13-9

Basic information

• Product Name: 2'-METHOXY-3-PHENYLPROPIOPHENONE
• Synonyms: 2'-METHOXY-3-PHENYLPROPIOPHENONE
• CAS NO: 22618-13-9
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Mol File: 22618-13-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 387.431°C at 760 mmHg
• Flash Point: 172.062°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 2'-METHOXY-3-PHENYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHOXY-3-PHENYLPROPIOPHENONE(22618-13-9)
• EPA Substance Registry System: 2'-METHOXY-3-PHENYLPROPIOPHENONE(22618-13-9)

Safety Data

• Hazardous Substances Data: 22618-13-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O2/c1-18-16-10-6-5-9-14(16)15(17)12-11-13-7-3-2-4-8-13/h2-10H,11-12H2,1H3

Upstream product

• 6948-61-4 (E)-1-(2-methoxyphenyl)-3-phenylprop-2-en-1-one 
• 103-63-9 1-phenyl-2-bromoethane 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 14371-10-9 (E)-3-phenylpropenal 
• 106-94-5 propyl bromide 
• 31600-86-9 2-methoxyphenyllithium 
• 104-53-0 3-phenyl-propionaldehyde 
• 766-51-8 2-Chloroanisole 
• 591-50-4 iodobenzene 
• 58824-49-0 1-(2-methoxyphenyl)prop-2-en-1-ol 
• 579-74-8 2-Methoxyacetophenone 
• 100-51-6 benzyl alcohol 
• 40524-62-7 1-(2-methoxyphenyl)-3-phenyl-2-propene-1-one 
• 5720-06-9 2-Methoxyphenylboronic acid 

Downstream Products

• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 4982-12-1 1-Acetoxy-1-<2-methoxy-benzoyl>-2-phenyl-aethan 
• 20760-12-7 1-(2-hydroxyphenyl)-3-phenyl-1-propanol 
• 13524-55-5 trans-3-Phenyl-1-(2-hydroxy-phenyl)-propen-1 
• 102560-18-9 2-benzyl-1-(2-methoxyphenyl)-3-phenylpropan-1-one 

Relevant articles and documents

Nickel-catalyzed α-alkylation of ketones with benzyl alcohols

We reported an efficient method for α-alkylation of ketones with benzyl alcohols using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts. A wide range of ketones and benzyl alcohols were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives.

Preparation method of novel aromatic ketone compound

The invention discloses a preparation method of a novel aromatic ketone compound. According to the preparation method, an aromatic carboxylic acid compound and an aromatic olefin compound are used asreaction raw materials, triphenylphosphine is taken as a deoxidizing reagent, Methylenene blue is taken as a photocatalyst, stirring and reacting are carried out at room temperature in an N,N-dimethylacetamide solvent under the irradiation of a white light lamp in a nitrogen atmosphere and under the condition of taking 2,4,6-trimethylpyridine as an alkali, thereby obtaining a target product, namely the aromatic ketone compound. The method has the advantages of mild reaction conditions, simplicity in operation, low cost, convenience in purification, environmental friendliness and the like.

Arylation of Aldehydes to Directly Form Ketones via Tandem Nickel Catalysis

A nickel-catalyzed arylation of both aliphatic and aromatic aldehydes proceeds with air-stable (hetero)arylboronic acids, with an exceptionally wide substrate scope. The neutral condition tolerates acidic hydrogen and sensitive polar groups and also preserves α-stereocenters of some chiral aldehydes. Interestingly, this nickel(0) catalysis does not follow common 1,2-insertion of arylmetal species to aldehydes and β-hydrogen elimination.