2265-64-7

Basic information

• Product Name: DEXAMETHASONE ISONICOTINATE
• Synonyms: Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(4-pyridinylcarbonyl)oxy-, (11.beta.,16.alpha.)-;9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-isonicotinate;9-Fluoro-11β,17-dihydroxy-21-isonicotinoyloxy-16α-methylpregna-1,4-diene-3,20-dione;Auxiloson;Voren;isonicotin [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-3-keto-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester;DEXAMETHASONE ISONICOTINATE;DEXAMETHASONE 21-ISONICOTINATE
• CAS NO: 2265-64-7
• Molecular Formula: C₂₈H₃₂FNO₆
• Molecular Weight: 497.56
• EINECS: 218-866-5
• Mol File: 2265-64-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 256°C
• Boiling Point: 676 °C at 760 mmHg
• Flash Point: 362.6 °C
• Appearance: /
• Density: 1.1972 (estimate)
• Vapor Pressure: 3.39E-19mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• Solubility: Practically insoluble in water, slightly soluble in anhydrous ethanol and in acetone.
• PKA: 11.92±0.70(Predicted)
• CAS DataBase Reference: DEXAMETHASONE ISONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: DEXAMETHASONE ISONICOTINATE(2265-64-7)
• EPA Substance Registry System: DEXAMETHASONE ISONICOTINATE(2265-64-7)

Safety Data

• Hazardous Substances Data: 2265-64-7(Hazardous Substances Data)

Usage

Description

DEXAMETHASONE ISONICOTINATE is a synthetic glucocorticoid, which is a derivative of dexamethasone. It possesses potent anti-inflammatory and immunosuppressive properties, making it a versatile pharmaceutical agent for various medical applications. This white or almost white crystalline powder is known for its effectiveness in treating a wide range of conditions, including allergies, inflammations, and autoimmune disorders.

Uses

Used in Pharmaceutical Industry:
DEXAMETHASONE ISONICOTINATE is used as an anti-inflammatory and anti-allergic agent for the treatment of various conditions such as allergies, asthma, rheumatoid arthritis, and other autoimmune disorders. Its potent anti-inflammatory action helps in reducing inflammation and alleviating symptoms associated with these conditions.
Used in Oral Administration:
DEXAMETHASONE ISONICOTINATE is used as an oral medication for the management of severe inflammation and allergic reactions. Its oral administration allows for easy absorption and rapid onset of action, providing quick relief from symptoms.
Used in Inhalation Therapy:
In the field of respiratory medicine, DEXAMETHASONE ISONICOTINATE is used as an inhaled medication for the treatment of asthma and chronic obstructive pulmonary disease (COPD). Inhaled administration helps in targeting the drug directly to the lungs, reducing systemic side effects and providing localized relief.
Used in Topical Applications:
DEXAMETHASONE ISONICOTINATE is used as a topical medication for the treatment of skin conditions such as eczema, dermatitis, and psoriasis. Its topical application allows for direct action on the affected area, reducing inflammation and promoting healing.
Used in Parenteral Administration:
DEXAMETHASONE ISONICOTINATE is also used for parenteral administration, which includes intravenous, intramuscular, and subcutaneous injections. This route of administration is particularly useful in cases where rapid systemic effects are required, such as in the treatment of severe allergic reactions or during emergency situations.

InChI:InChI=1/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1