22728-89-8

Basic information

• Product Name: 4-methyl hydrogen D-aspartate hydrochloride
• Synonyms: 4-methyl hydrogen D-aspartate hydrochloride;B-methylesterD-aspartateHCl;B-methylesterD-aspartatehydrochloride;BETA-METHYLESTER-D-ASPARTATEHCL;β-Methyl (2R)-aspartate ester hydrochloride;(R)-2-Amino-4-methoxy-4-oxobutanoic acid hydrochloride;D-Aspartic acid-b-methyl ester hydrochloride
• CAS NO: 22728-89-8
• Molecular Formula: C₅H₉NO₄*ClH
• Molecular Weight: 184.59814
• EINECS: 245-179-8
• Mol File: 22728-89-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 329 °C at 760 mmHg
• Flash Point: 152.8 °C
• Appearance: /
• Vapor Pressure: 3.6E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-methyl hydrogen D-aspartate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl hydrogen D-aspartate hydrochloride(22728-89-8)
• EPA Substance Registry System: 4-methyl hydrogen D-aspartate hydrochloride(22728-89-8)

Safety Data

• Hazardous Substances Data: 22728-89-8(Hazardous Substances Data)

Usage

General Description

4-Methyl hydrogen D-aspartate hydrochloride is a chemical compound with properties that are useful in research related to neuroscience. Its structure is similar to a neurotransmitter in the brain known as glutamate and is often used as a selective agonist for a type of glutamate receptor known as the NMDA receptor. This receptor plays a crucial role in memory and learning, and substances that can selectively stimulate or block these receptors are highly valuable for studies in neuroscience. With its selective action, this compound is helpful in understanding the functions of NMDA receptors and investigating treatments for diseases like Alzheimer's and schizophrenia, where these receptors are believed to malfunction.

InChI:InChI=1/C5H9NO4.ClH/c1-10-4(7)2-3(6)5(8)9;/h3H,2,6H2,1H3,(H,8,9);1H/t3-;/m1./s1

Upstream product

• 67-56-1 methanol 
• 1783-96-6 (2R)-aspartic acid 
• 56-84-8 L-Aspartic acid 

Downstream Products

• 28862-78-4 (+)-N-Cbz-β-methyl-D-aspartate 
• 34582-30-4 L-asparic acid C₁-t-butyl C₄-methyl diester hydrochloride 
• 124184-67-4 (2R)-2-[(tert-butoxycarbonyl)amino]-4-methoxy-4-oxobutanoic acid 
• 86070-35-1 D-2-amino-3-methylaminopropionic acid 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF (R)-4-(1-(6-(4-(TRIFLUOROMETHYL)BENZYL)-6-AZASPIRO[2.5]OCTANE-5-CARBOXAMIDO)-CYCLOPROPYL) BENZOIC ACID OR A SALT THEREOF

The present invention provides a process for preparing (R)-6-(tert-butoxycarbonyl)-6- azaspiro[2.5]octane-5-carboxylic acid (SM1), said process comprising the step of: iv) converting a compound of formula (VII) into a compound of formula (VIII) using a Wittig reagent in a suitable solvent; v) reacting through the Makosza reaction the compound of Formula (VIII) using bromoform and a suitable base to obtain cyclopropane compound of Formula (IX); and vi) removing bromine atoms in the presence of a reducing agent and a base in an alcoholic solvent thus obtaining (SM1). The invention relates also to a process for the conversion of the compound (SM1) for preparing (R)- 4-(1-(6-(4-(trifluoromethyl)benzyl)-6-azaspiro[2.5]octane-5-carboxamido)cyclopropyl) benzoic acid (IV) or a salt thereof. The salt is preferably the sodium salt, more preferably the polymorphic form A of sodium (R)-4-(1-(6-(4-(trifluoromethyl)benzyl)-6- azaspiro[2.5]octane-5-carboxamido)-cyclopropyl) benzoate characterized by a powder XRD spectrum with peaks at values of the angle 2θ ±0.2° of 4.3, 5.0, 5.8, 6.4, 7.1, 8.3, 8.7, 12.8, 15.3, 15.9.

A convenient method of preparation arab League throws cillin sodium

The invention discloses a convenient method for preparing aspoxicillin sodium. The method comprises the steps of adding D-aspartic acid into a mixed solution of thionyl chloride and methanol, reacting to prepare D-aspartic acid methyl ester hydrochloride, reacting the D-aspartic acid methyl ester hydrochloride with an aqueous solution of methylamine to obtain aspartic formamide, protecting the first amino on the aspartic formamide by using trifluoroacetyl, then reacting the aspartic formamide with carbonyldimidazole to form an active mixed acid anhydride, condensing the active mixed acid anhydride with an amoxicillin triethylamine salt, finally removing the protective ground and forming a sodium salt under the alkali condition to obtain a crude aspoxicillin product of the target product, and refining the crude product to obtain the high-purity aspoxicillin sodium finished product. The method has the advantages that the reagents are cheap, readily available and low in toxicity and environmental pressure, the process operation is compact and stable, the purity of the product is high and the like.

A 10th factor inhibitor and its preparation method and application (by machine translation)

The invention relates to a 10th factor inhibitor and its preparation and application, the 10th factor inhibitor has the structure of formula I, the invention inhibitors to alpha-amino acid as a template, respectively through the amide, carbamate, or urea to the branched chain is formed by a series of novel structure of the compound, this kind of compound can be effectively with the 10th factor binding, prevent the formation of thrombus. (by machine translation)