22876-22-8

Basic information

• Product Name: 2-Mercapto-5-methylbenzoxazole
• Synonyms: SALOR-INT L470805-1EA;5-METHYL-2,3-DIHYDRO-1,3-BENZOXAZOLE-2-THIONE;5-METHYL-1,3-BENZOXAZOLE-2(3H)-THIONE;5-METHYLBENZOXAZOLINE-2-THIONE;2-MERCAPTO-5-METHYLBENZOXAZOLE;5-Methylbenzoxazoline-2-thione,97%;5-Methyl-2(3H)-benzoxazolethione, 97%;2-Mercapato-6-methylbenzoxazole
• CAS NO: 22876-22-8
• Molecular Formula: C₈H₇NOS
• Molecular Weight: 165.21
• Mol File: 22876-22-8.mol
• Article Data: 42

Chemical Properties

• Melting Point: 223-225°C
• Boiling Point: 260.9 °C at 760 mmHg
• Flash Point: 111.6 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 0.0119mmHg at 25°C
• Refractive Index: 1.682
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.26±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-Mercapto-5-methylbenzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Mercapto-5-methylbenzoxazole(22876-22-8)
• EPA Substance Registry System: 2-Mercapto-5-methylbenzoxazole(22876-22-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 22876-22-8(Hazardous Substances Data)

Usage

General Description

2-Mercapto-5-methylbenzoxazole, also known as MMB, is a chemical compound with the molecular formula C8H7NOS. It is a benzoxazole derivative containing a mercapto group and a methyl group attached to the benzene ring. MMB is commonly used as a photoinitiator in the polymerization process and as a stabilizer in the presence of ultraviolet light. It is also utilized as an intermediate for the synthesis of various pharmaceutical and agrochemical products. Furthermore, MMB has shown potential as a corrosion inhibitor and a fluorescent probe for detecting metal ions. However, exposure to MMB should be limited, as it can be irritating to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H7NOS/c1-5-2-3-7-6(4-5)9-8(11)10-7/h2-4H,1H3,(H,9,11)

Upstream product

• 22876-15-9 5-methylbenzo[d]oxazol-2(3H)-one 
• 140-89-6 potassium ethyl xanthogenate 
• 95-84-1 3-amino-4-hydroxytoluene 
• 75-15-0 carbon disulfide 
• 119-33-5 4-methyl-2-nitrophenol 
• 103-71-9 phenyl isocyanate 
• 103-72-0 phenyl isothiocyanate 
• 79558-90-0 N¹-methyl-N²-(2-hydroxy-5-methylphenyl)thiourea 
• 79558-91-1 N-(2-hydroxy-5-methylphenyl)-N'-phenylthiourea 
• 10531-78-9 5-methyl-1,3-benzoxazole 
• 137-26-8 Thiram 
• 128-04-1 sodium dimethyldithiocarbamate 

Downstream Products

• 38519-93-6 (5-methyl-benzooxazol-2-yl)-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine 
• 3770-60-3 2-chloro-5-methyl-1,3-benzoxazole 
• 811807-57-5 N-benzhydryl-2-(5-methyl-benzooxazol-2-ylsulfanyl)-acetamide 
• 439608-30-7 5-methyl-2-methylsulfanyl-benzooxazole 
• 199292-96-1 5-methyl-2-(4-methyl-1,4-diazepan-1-yl)benzoxazole 
• 445260-71-9 2-[(5-methylbenzo[d]oxazol-2-yl)thio]-N-(9H-fluoren-9-yl)acetamide 
• 1237542-35-6 2-(5-methyl-benzoxazol-2-yl)-sulfanyl-N-[4-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)phenyl]acetamide 
• 1334386-29-6 (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid methyl ester trifluoroacetate 
• 1334386-00-3 (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid 
• 1334386-01-4 (S)-2-(2-hydroxy-5-methylphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate 
• 1352614-96-0 C₁₇H₁₅N₃O₃S 
• 1352614-97-1 C₁₇H₁₄ClN₃O₂S 
• 1352614-98-2 C₁₇H₁₄N₄O₄S 

Relevant articles and documents

Synthesis of benzoxazole associated benzothiazine-4-ones and their in vitro and in silico antimicrobial, antioxidant activities

In present study, a series of 3-[(5-methyl-1,3-benzoxazol-2-yl)amino]-2-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-ones (6a-n) were synthesized and elucidated by elemental, FT-IR, 1H & 13C NMR and LC-MS studies. The in vitro antibacter

Three-Component Synthesis of 2-Alkylthiobenzoazoles in Aqueous Media

A highly efficient three-component protocol for the synthesis of the 2-alkylthiobenzoazoles is described. Tetramethylthiuram disulfide (TMTD) cyclized with o -aminothiophenols, generating the intermediate 2-mercaptobenzothiazoles, and the successive C-S coupling with halogenated alkanes afforded a series of 2-alkyl-substituted thiobenzothiazoles smoothly in a one-pot process. This procedure could also be utilized for the preparation of 2-alkyl-substituted thiobenzoxazoles and 2-alkyl-substituted thiobenzimidazoles. Inexpensive and easily available starting materials, metal catalyst-free, broad substrate scope, and water as solvent are the features of this protocol.

Metal-free C–H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source

A facile and effective C–H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C–H mercaptalization of heteroarenes and a simple reaction system.