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22890-52-4

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22890-52-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 22890-52-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,8,9 and 0 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22890-52:
(7*2)+(6*2)+(5*8)+(4*9)+(3*0)+(2*5)+(1*2)=114
114 % 10 = 4
So 22890-52-4 is a valid CAS Registry Number.

22890-52-4Relevant articles and documents

Improved Preparation of the Clathrate Host Compound Tri-o-thymotide and Related Trisalicylide Derivatives

Gnaim, Jallal M.,Green, Bernard S.,Arad-Yellin, Rina,Keehn, Philip M.

, p. 4525 - 4529 (2007/10/02)

In order to improve the relatively low yield (ca. 35percent) previously observed in the synthesis of tri-o-thymotide (TOT, 1) from o-thymotic acid (2), the cyclodehydration was studied using a variety of conditions.The low yield is due to the formation of di-o-thymotide (DOT, 3), previously reported, and at least three other products (4-6), which apparently result from the acid-catalyzed decarboxylation of 2 and subsequent condensation with thymol (7).Using pyridine as a solvent, side-product formation is inhibited.Under appropriate conditions, namely, neat POCl3 at 50 deg C, the yield of 1 is 93percent.Other salicylic acid derivatives also give high yields of the corresponding "trimers" under these conditions, thus providing a general, improved preparation of a family of potential clathrate host substances.

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