229006-88-6

Basic information

• Product Name: 2-(4-Methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid
• Synonyms: 2-(4-Methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid
• CAS NO: 229006-88-6
• Molecular Formula: C19H18O2
• Molecular Weight: 278.351
• Mol File: 229006-88-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 189 - 190 °C (acetonitrile)
• CAS DataBase Reference: 2-(4-Methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid(229006-88-6)
• EPA Substance Registry System: 2-(4-Methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid(229006-88-6)

Safety Data

• Hazardous Substances Data: 229006-88-6(Hazardous Substances Data)

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 229007-63-0 methyl 2-bromo-6,7-dihydro-5H-benzocycloheptene-8-carboxylate 
• 36393-42-7 4-(4-methylphenyl)benzaldehyde 
• 50670-50-3 p-(p-tolyl)benzonitrile 
• 350022-60-5 5-oxo-3-p-tolyl-6,7,8,9-tetrahydro-5H-benzocycloheptene-6-carboxylic acid methyl ester 
• 350022-61-6 5-hydroxy-3-p-tolyl-6,7,8,9-tetrahydro-5H-benzocycloheptene-6-carboxylic acid methyl ester 
• 898792-67-1 5-(4-bromo-phenyl)-5-oxo-pentanoic acid ethyl ester 
• 22647-95-6 5-(4-bromophenyl)pentanoic acid 
• 87779-78-0 3-bromo-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one 
• 35333-26-7 4-bromo-δ-oxobenzenepentanoic acid 
• 108-86-1 bromobenzene 
• 5205-39-0 ethyl glutaroyl chloride 
• 724767-20-8 ethyl 2-(4-methylphenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxylate 
• 263765-67-9 3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbaldehyde 

Downstream Products

• 229005-52-1 2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide 
• 229005-80-5 TAK-779 
• 229008-30-4 N-(4-chloromethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 
• 229008-29-1 N-(4-hydroxymethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 
• 229004-26-6 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide 
• 229005-66-7 N-(4-((N-3-hydroxypropyl-N-methyl)aminomethyl)phenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 
• 229005-69-0 N-(4-((N-methyl-N-(pentan-3-yl))aminomethyl)phenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 
• 229005-85-0 N-(4-((N-tetrahydrothiopyran-4-yl-N-methyl)aminomethyl)phenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 
• 229005-87-2 N-(4-((N-ethyl-N-tetrahydropyran-4-yl)aminomethyl)phenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxamide 
• 1031771-45-5 N-(4-N-BOC-aminomethylphenyl)-2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide 

Relevant articles and documents

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists

CCR2 and CCR5 receptors play a key role in the development and progression of several inflammatory, cardiovascular and autoimmune diseases. Therefore, dual targeting of both receptors appeals as a promising strategy for the treatment of such complex, mult

Convenient efficient synthesis of TAK-779, a nonpeptide CCR5 antagonist: Development of preparation of various ammonium salts using trialkylphosphite and N-halogenosuccinimide

A convenient and efficient synthesis of TAK-779 (1a), a nonpeptide CCR5 antagonist, has been achieved. The new methylation of tertiary amine (2) using trimethyl phosphite and N-chlorosuccinimide, followed by the addition of HCl led to ammonium chloride (1a) in 89% isolated yield without requiring a chromatographic method. By this preparation, ammonium methanesulfonate (1e) could be obtained in 75% isolated yield.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.