22923-00-8

Basic information

• Product Name: N-(2,4-dichlorophenyl)formamide
• Synonyms: N-(2,4-dichlorophenyl)formamide;Einecs 245-331-3;2',5'-DICHLOROFORMANILIDE
• CAS NO: 22923-00-8
• Molecular Formula: C₇H₅Cl₂NO
• Molecular Weight: 190.0267
• EINECS: 245-331-3
• Mol File: 22923-00-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 158-159 °C
• Boiling Point: 354.8°Cat760mmHg
• Flash Point: 168.4°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 3.27E-05mmHg at 25°C
• Refractive Index: 1.622
• PKA: 13.19±0.70(Predicted)
• CAS DataBase Reference: N-(2,4-dichlorophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-dichlorophenyl)formamide(22923-00-8)
• EPA Substance Registry System: N-(2,4-dichlorophenyl)formamide(22923-00-8)

Safety Data

• Hazardous Substances Data: 22923-00-8(Hazardous Substances Data)

Usage

General Description

N-(2,4-Dichlorophenyl)formamide is a chemical compound with the formula C7H5Cl2NO. It is also known by the trade name Caswell No. 300A. This chemical is a white, crystalline solid that is slightly soluble in water and soluble in organic solvents. It is primarily used as an intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds. N-(2,4-Dichlorophenyl)formamide is also used in research and development activities. There is limited information available regarding its toxicological properties and potential environmental impacts.

InChI:InChI=1/C7H5Cl2NO/c8-5-1-2-7(10-4-11)6(9)3-5/h1-4H,(H,10,11)

Upstream product

• 64-18-6 formic acid 
• 554-00-7 2,4-Dichloroaniline 
• 103-70-8 Formanilid 
• 2258-42-6 formyl acetic anhydride 
• 56-23-5 tetrachloromethane 
• 7791-25-5 sulfuryl dichloride 
• 7782-50-5 chlorine 
• 7719-09-7 thionyl chloride 
• 67-66-3 chloroform 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 42910-17-8 N-chloro formanilide 
• 72773-04-7 N-formylbenzotriazole 
• 141-53-7 sodium formate 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 107917-40-8 N'-(4-chloro-phenyl)-N-(2,4-dichloro-phenyl)-N-formyl-urea 
• 95845-32-2 2,4-Dichlor-phenylimino-kohlensaeure-thio-<4-nitro-phenylester>-chlorid 
• 96431-15-1 2,4-Dichlor-phenylimino-kohlensaeure-thiopentachlorphenylester-chlorid 
• 2666-70-8 2,4-dichlorophenyl isocyanide dichloride 
• 35113-88-3 N-methyl-2,4-dichloro-aniline 
• 1354946-03-4 4-{[1-(2,4-dichlorophenyl)-1H-tetrazol-5-yl]methyl}morpholine 
• 6574-98-7 2,4-dichlorobenzylnitrile 
• 952958-68-8 1-(2,4-dichlorophenyl)-1H-imidazole-4-carboxylic acid 

Relevant articles and documents

Design, synthesis and anticancer evaluation of 3-methyl-1H-indazole derivatives as novel selective bromodomain-containing protein 4 inhibitors

Bromodomain-containing Protein 4 (BRD4), an ‘epigenetic reader’, regulates chromatin structure and gene expression via recognizing and binding acetylated lysine in histones. BRD4 has become a therapeutic target for cancers because it promotes the expression of the tumor genes, such as c-Myc, NF-κB, and Bcl-2. In this study, a new series of 3-methyl-1H-indazole derivatives were designed via virtual screening and structure-based optimization. All compounds were synthesized and evaluated for their inhibitory activities to BRD4-BD1 and their antiproliferative effects in cancer cell lines. Among them, several compounds (such as 9d, 9u and 9w) exhibited strong BRD4-BD1 affinities and inhibition activities, and potently suppressed MV4;11 cancer cell line proliferation. Among them, compound 9d showed excellent selectivity for BRD4 and effectively suppressed c-Myc, the downstream protein of BRD4. This study provided new lead compounds for further biological evaluation on BRD4.

New catalytic performance of immobilized sulfuric acid on activated charcoal for n-formylation of amines with ethyl formate

Summary: Simple and highly efficient procedure for N-formylation of various amines was carried out in the presence of the immobilized sufuric acid on activated charcoal as an efficient promoter system. All reactions were taken place in refluxing ethyl formate (54 °C) under mild reaction conditions. The product formamides were obtained in high to excellent yields (83-95%) within 4-80 min.

Design and Synthesis of Novel 4-Phenoxyquinolines Bearing 3-Hydrosulfonylacrylamido or 1H-Imidazole-4-carboxamido Scaffolds as c-Met Kinase Inhibitors

A series of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing (E)-3-hydrosulfonylacrylamido or 1H-imidazole-4-carboxamido moieties were designed, synthesized and evaluated for their cytotoxicity against A549, MKN-45, and HT-29 cancer cell lines in vitro. All the target compounds showed moderate to significant cytotoxic activity against the tested cells with IC50 values ranging from 0.13 to 2.65 μM. Five of them were further examined for their inhibitory activity against c-Met kinase, which identified compound 30 as a promising agent (c-Met IC50 = 1.52 nM) with IC50 values of 0.24, 0.45, and 0.13 μM against HT-29, MKN-45, and A549 cells, respectively.