22934-23-2

Basic information

• Product Name: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE
• Synonyms: 4,6-DIMETHYL-3-NITROPYRIDIN-2-AMINE;4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE
• CAS NO: 22934-23-2
• Molecular Formula: C₇H₉N₃O₂
• Molecular Weight: 167.17
• Mol File: 22934-23-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 164 °C
• Boiling Point: 318.4°Cat760mmHg
• Flash Point: 146.4°C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 0.000362mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• PKA: 3.15±0.50(Predicted)
• CAS DataBase Reference: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE(22934-23-2)
• EPA Substance Registry System: 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE(22934-23-2)

Safety Data

• Hazardous Substances Data: 22934-23-2(Hazardous Substances Data)

Usage

General Description

4,6-Dimethyl-3-nitro-pyridin-2-ylamine is a chemical compound with the molecular formula C7H8N4O2. It is a yellow crystalline solid with a slightly water-soluble nature. 4,6-DIMETHYL-3-NITRO-PYRIDIN-2-YLAMINE is also known as 2-Amino-4,6-dimethyl-3-nitropyridine and is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is often utilized as a building block in the production of organic compounds and is also used as a raw material in the manufacturing of dyes and pigments. Additionally, 4,6-Dimethyl-3-nitro-pyridin-2-ylamine may have potential applications in the field of medicinal chemistry and may serve as a valuable reagent in research and chemical processes.

InChI:InChI=1/C7H9N3O2/c1-4-3-5(2)9-7(8)6(4)10(11)12/h3H,1-2H3,(H2,8,9)

Upstream product

• 146580-30-5 2-Amino-1,4-dihydro-4,5-dimethyl-3-nitropyridin 
• 71090-35-2 1,1-diamino-2-nitroethene 
• 123-54-6 acetylacetone 
• 13514-88-0 nitroacetamidine 
• 3102-33-8 trans-3-penten-2-one 
• 89853-68-9 (4,6-dimethyl-pyridin-2-yl)-nitro-amine 
• 1336-21-6 ammonium hydroxide 
• 5407-87-4 2-Amino-4,6-dimethylpyridine 

Downstream Products

• 50850-16-3 2,3-diamino-4,6-dimethylpyridine 
• 133240-06-9 5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine 
• 133240-46-7 L-158,809 
• 133240-47-8 5,7-Dimethyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine 
• 133051-72-6 2-Butyl-5,7-dimethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine 
• 133052-12-7 2-Butyl-5,7-dimethyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine 
• 90008-31-4 2,5-diamino-4,6-dimethyl-pyridine 
• 1197880-16-2 3-(4-bromobenzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine 
• 1197880-18-4 (E)-methyl 3-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate 
• 1197880-22-0 (E)-methyl 3-(4-((2-isopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)acrylate 
• 1197880-15-1 (E)-3-(4-((5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol 
• 1197880-19-5 (E)-3-(4-((5,7-dimethyl-2-isopropyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)prop-2-en-1-ol 
• 1198009-55-0 (E)-3-(4-(3-(4-isopropylpiperazin-1-yl)prop-1-en-1-yl)benzyl)-5,7-dimethyl-2-propyl-3H-imidazo[4,5-b]pyridine 
• 1197880-20-8 3-(4-bromobenzyl)-2-isopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

Innovative approaches to the imidazo[4,5-b]pyridine ring system. Development of an efficient process for industrial-scale production of a key intermediate for potent angiotensin II receptor antagonists

Two syntheses of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (3), an important intermediate for the synthesis of several potent angiotensin II antagonists, have been investigated. The first route involves conversion of 1,1-bis(methylthio)-2-nitroethene (17) to 2-ammo-4,6-dimethyl-3-nitropyridine (6); catalytic hydrogenation of 6 in propionic acid gave 3 in high yield. In the second synthesis, propionitrile is converted to imidate hydrochloride 15·HCl which is neutralised and reacted with aminoacetonitrile in the presence of acetylacetone to give 3 in 55% overall yield. The propionitrile route was scaled up to produce 3 in the pilot plant.

Polyfunctional pyridines from nitroacetamidine and β-diketones. A useful synthesis of substituted imidazo[4,5-b]pyridines and related compounds

Nitroacetamidine undergoes a useful cyclocondensation with β-diketones to produce substituted 2-amino-3-nitropyridines. Use of an acylpyruvate generates hitherto unreported 2-amino-3-nitropyridine-4-carboxylates. These may be converted easily to functionalized imidazo[4,5-b]pyridines and oxazolo[5,4-b]pyridines.

Angiotensin II antagonists incorporating a substituted thiophene or furan

There are disclosed substituted thiophene and furan derivatives of Formula I which are useful as angiotensin II antagonists. STR1