22962-86-3

Basic information

• Product Name: 4-methyl-3-phenyl-2-(N-phenylimino)-1,3-thiazoline
• Synonyms: 4-methyl-3-phenyl-2-(N-phenylimino)-1,3-thiazoline
• CAS NO: 22962-86-3
• Molecular Weight: 266.367
• Mol File: 22962-86-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-methyl-3-phenyl-2-(N-phenylimino)-1,3-thiazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-3-phenyl-2-(N-phenylimino)-1,3-thiazoline(22962-86-3)
• EPA Substance Registry System: 4-methyl-3-phenyl-2-(N-phenylimino)-1,3-thiazoline(22962-86-3)

Safety Data

• Hazardous Substances Data: 22962-86-3(Hazardous Substances Data)

Upstream product

• 102-08-9 N,N-diphenylthiourea 
• 598-31-2 1-bromoacetone 
• 127040-65-7 2-Allyl-1,3-diphenyl-isothiourea 
• 127040-71-5 [4-Iodomethyl-3-phenyl-thiazolidin-(2Z)-ylidene]-phenyl-amine 
• 103-72-0 phenyl isothiocyanate 
• 78-95-5 chloroacetone 
• 62-53-3 aniline 
• 3898-08-6 1,1-diphenylthiourea 
• 67-64-1 acetone 
• 622-16-2 1,3-Diphenylcarbodiimide 
• 24653-75-6 1-mercaptopropan-2-one 
• 101279-97-4 4-methyl-3-phenyl-2-phenylimino-thiazolidin-4-ol 

Downstream Products

• 5316-80-3 4-methyl-3-phenyl-1,3-thiazole-2(3H)-thione 

Relevant articles and documents

Efficient synthetic procedure to new 2-imino-1,3-thiazolines and thiazolidin-4-ones promoted by acetonitrile electrogenerated base

A novel and convenient strategy is described for the regioselective conversion of N,N′-disubstituted thioureas and 1,2-dielectrophiles into the highly biologically valuable 2-imino-thiazoline and 2-imino thiazolidine-4-one derivatives. The synthesis proce

A convenient one-pot synthesis of thiazol-2-imines: application in the construction of pifithrin analogues

For the first time a reaction intermediate has been isolated giving further insight into the mechanism of thiazol-2-imine formation. The first step of the reaction requires a basic medium, while the second step is an acid mediated E1 elimination reaction. An efficient one-pot synthesis of substituted thiazol-2-imines have been achieved by the condensation of carbonyl compounds with thioureas and 1,3-disubstituted thioureas using 1,1′-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT). Unsymmetrical 1,3-disubstituted thioureas give regioselective products with symmetrical ketones, which are mainly governed by the pKas of NH protons of thiourea, whereas symmetrical 1,3-disubstituted thioureas give regioselective products with symmetrical carbonyl compounds owing to the regioselective bromination of ketones. The methodology is extended to access novel neurodegenerative drug candidate pifithrin-α analogues in good yields in shorter reaction time. This method is simple, versatile and is applicable for different 1,3-disubstituted thioureas as well as a range of carbonyl compounds.