23095-05-8

Basic information

• Product Name: 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE
• Synonyms: 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE;5-BROMO-2-METHOXYBENZENESULPHONYL CHLORIDE;5-BROMO-2-METHOXYBENZENE-1-SULFONYL CHLORIDE;5-BROMO-2-METHOXYBENZENE-1-SULPHONYL CHLORIDE;BUTTPARK 100\07-65;5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE 98%;5-Bromo-2-methoxybenzenesulfonyl chloride,98%;4-BroMo-2-(Methyloxy)benzenesulfonyl chloride
• CAS NO: 23095-05-8
• Molecular Formula: C₇H₆BrClO₃S
• Molecular Weight: 285.54
• Product Categories: blocks;Bromides;BuildingBlocks;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 23095-05-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 115-118 °C(lit.)
• Boiling Point: 362.251 °C at 760 mmHg
• Flash Point: 172.883 °C
• Appearance: white crystalline powder
• Density: 1.717
• Vapor Pressure: 4.08E-05mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 3093014
• CAS DataBase Reference: 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE(23095-05-8)
• EPA Substance Registry System: 5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE(23095-05-8)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 23095-05-8(Hazardous Substances Data)

Usage

Description

5-Bromo-2-methoxybenzenesulfonyl chloride is a benzenesulfonyl chloride derivative characterized by its white crystalline powder form. It is a chemical compound that holds potential in various synthetic applications due to its unique structure and reactivity.

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2-methoxybenzenesulfonyl chloride is used as a synthetic intermediate for the preparation of specific 1-bromo-3-heteroarylbenzene derivatives. These derivatives are crucial in the development of pharmaceutical compounds with targeted therapeutic properties.
Used in the Synthesis of 2-(5-bromo-2-methoxyphenyl)benzofuran:
5-BROMO-2-METHOXYBENZENESULFONYL CHLORIDE serves as a key building block in the synthesis of 2-(5-bromo-2-methoxyphenyl)benzofuran, a heterocyclic compound that may exhibit biological activities of interest in drug discovery.
Used in the Synthesis of 2-(5-bromo-2-methoxyphenyl)-1-methylpyrrole:
5-Bromo-2-methoxybenzenesulfonyl chloride is used as a reactant in the synthesis of 2-(5-bromo-2-methoxyphenyl)-1-methylpyrrole, which is another heterocyclic compound with potential applications in medicinal chemistry.
Used in the Synthesis of 2-(5-bromo-2-methoxyphenyl)benzoxazole:
This benzenesulfonyl chloride derivative is utilized in the preparation of 2-(5-bromo-2-methoxyphenyl)benzoxazole, contributing to the synthesis of bioactive molecules for pharmaceutical research.
Used in the Synthesis of N-(4-ethylbenzoyl)-2-methoxybenzenesulfonamide:
5-Bromo-2-methoxybenzenesulfonyl chloride is also used in the synthesis of N-(4-ethylbenzoyl)-2-methoxybenzenesulfonamide, which may have applications in the development of new pharmaceutical agents.

InChI:InChI=1/C7H6BrClO3S/c1-12-6-3-2-5(8)4-7(6)13(9,10)11/h2-4H,1H3

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 6358-77-6 5-bromo-2-methoxyaniline 

Downstream Products

• 23095-14-9 5-bromo-2-methoxybenzenesulfonamide 
• 847652-85-1 5-bromo-N-(4-chloro-5-isopropyl-3H-thiazol-2-ylidene)-2-methoxy-benzenesulfonamide 
• 439145-76-3 5-bromo-N-(3,5-dichlorophenyl)-2-methoxybenzenesulfonamide 
• 276259-23-5 methyl 3-{[(5-bromo-2-methoxyphenyl)sulfonyl]amino}-3-phenylpropanoate 
• 433694-10-1 5-bromo-N-cyclohexyl-2-methoxy-benzenesulfonamide 
• 197959-80-1 3-(5-bromo-2-methoxyphenylsulfonyloxy)-5-methylphenol 
• 1053234-79-9 (R)-2-(5-Bromo-2-methoxy-benzenesulfonylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 1053234-75-5 5-Bromo-N-[(R)-2-hydroxy-1-(1H-indol-3-ylmethyl)-ethyl]-2-methoxy-benzenesulfonamide 

Relevant articles and documents

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia

Accumulating researches have contributed much effect to discover novel chemotherapeutic drug for leukemia with expeditious curative effect, of which bromodomain-containing protein 4 (BRD4) inhibitor is considered as a eutherapeutic drug which has presented efficient cell proliferation suppression effect. In this study, we disclosed a series of phenylisoxazole sulfonamide derivatives as potent BRD4 inhibitors. Especially, compound 58 exhibited robust inhibitory potency toward BRD4-BD1 and BRD4-BD2 with IC50 values of 70 and 140 nM, respectively. In addition, compound 58 significantly suppressed cell proliferation of leukemia cell lines HL-60 and MV4-11 with IC50 values of 1.21 and 0.15 μM. In-depth study of the biological mechanism of compound 58 exerted its tumor suppression effect via down-regulating the level of oncogene c-myc. Moreover, in vivo pharmacokinetics (PK) study was conducted and the results demonstrated better pharmacokinetics features versus (+)-JQ1. In summary, our study discovers that compound 58 represents as a novel BRD4 inhibitor for further investigation in development of leukemia inhibitor with potentiality.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor

Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme crucial for bone matrix mineralization via its ability to hydrolyze extracellular inorganic pyrophosphate (ePPi), a potent mineralization inhibitor, to phosphate (Pi). B

1,3,5-TRIAZINE-2-AMINE DERIVATIVES, PREPARATION THEREOF AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF

The present invention relates to compounds corresponding to formula (I) in which: - R1 represents a substituted phenyl; - R2 represents: - a substituted phenyl; - a heteroaromatic group, the said group being unsubstituted or substituted one or more times; - R3 represents a group Alk; - R4 represents a hydrogen atom or a (C1-C4)alkyl; - R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; - or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; - R6 represents a group -COOAlk, a group -CONH2 or a group -NHSO2 Alk; - Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use