230955-73-4

Basic information

• Product Name: 2,2,2-trifluoro-N-(4-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-quinazolin-6-yloxy}-butyl)-N-(2-methanesulfonyl-ethyl)-acetamide
• CAS NO: 230955-73-4
• Molecular Weight: 658.677
• Mol File: 230955-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2,2-trifluoro-N-(4-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-quinazolin-6-yloxy}-butyl)-N-(2-methanesulfonyl-ethyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-trifluoro-N-(4-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-quinazolin-6-yloxy}-butyl)-N-(2-methanesulfonyl-ethyl)-acetamide(230955-73-4)
• EPA Substance Registry System: 2,2,2-trifluoro-N-(4-{4-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-quinazolin-6-yloxy}-butyl)-N-(2-methanesulfonyl-ethyl)-acetamide(230955-73-4)

Safety Data

• Hazardous Substances Data: 230955-73-4(Hazardous Substances Data)

Upstream product

• 16064-10-1 6-hydroxyquinazolin-4(3H)-one 
• 179688-15-4 3,4-dihydro-4-oxoquinazolin-6-yl acetate 
• 202197-68-0 [2-(methylsulfonyl)ethyl]trifluoroacetamide 
• 230955-69-8 N-(4-bromobutyl)-N-(2-methanesulfonylethyl)-2,2,2-trifluoroacetamide 
• 230955-60-9 4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)quinazolin-6-ol 

Relevant articles and documents

Synthesis and SAR of potent EGFR/erbB2 dual inhibitors

A series of 6-alkoxy-4-anilinoquinazoline compounds was prepared and evaluated for in vitro inhibition of the erbB2 and EGFR kinase activity. The IC50 values of the best compounds were below 0.10 uM. Further, several of these compounds inhibit the growth of erbB2 and EGFR over-expressing tumor cell lines at concentrations below 1 uM.