2314-76-3

Basic information

• Product Name: N-M-TOLYLPHTHALIMIDE
• Synonyms: N-M-TOLYLPHTHALIMIDE;2-(3-methylphenyl)isoindole-1,3-dione;2-(3-methylphenyl)isoindoline-1,3-quinone
• CAS NO: 2314-76-3
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.25
• Mol File: 2314-76-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 418.4 °C at 760 mmHg
• Flash Point: 197 °C
• Appearance: /
• Density: 1.296 g/cm³
• Vapor Pressure: 3.29E-07mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: N-M-TOLYLPHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-M-TOLYLPHTHALIMIDE(2314-76-3)
• EPA Substance Registry System: N-M-TOLYLPHTHALIMIDE(2314-76-3)

Safety Data

• Hazardous Substances Data: 2314-76-3(Hazardous Substances Data)

Usage

General Description

N-M-Tolylphthalimide, also known as N-methyltolylphthalimide, is a chemical compound with the molecular formula C14H11NO2. It is a white to light yellow crystal that is commonly used as an intermediate in the production of various dyes and pigments. N-M-Tolylphthalimide is also used as a vulcanization accelerator in the rubber industry, where it improves the elasticity, strength, and durability of rubber products. Additionally, it is utilized in the synthesis of pharmaceuticals and agrochemicals. This chemical is considered to be relatively low in toxicity, but proper safety precautions should still be taken when handling it.

InChI:InChI=1/C15H11NO2/c1-10-5-4-6-11(9-10)16-14(17)12-7-2-3-8-13(12)15(16)18/h2-9H,1H3

Upstream product

• 85-44-9 phthalic anhydride 
• 108-44-1 1-amino-3-methylbenzene 
• 85-72-3 N-meta-tolyl phthalamic acid 
• 73357-42-3 2-(3-methylphenyl)-2,3-dihydro-1H-isoindole 
• 670-54-2 ethenetetracarbonitrile 
• 136918-14-4 phthalimide 
• 17933-03-8 m-tolylboronic acid 
• 178933-91-0 [3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]acetic acid 
• 108-88-3 toluene 
• 524-38-9 N-hydroxyphthalimide 
• 5672-90-2 N-(trifluoromethyl)acyloxyphthalimide 
• 3481-09-2 N-chlorophthalimide 
• 83-33-0 inden-1-one 
• 26919-48-2 tri-m-tolylbismuth 

Downstream Products

• 85-72-3 N-meta-tolyl phthalamic acid 
• 314-81-8 2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione 
• 129747-78-0 N-(3-Bromomethylphenyl)phthalimide 
• 205759-45-1 3-N-phthalimidobenzaldehyde 
• 1532556-62-9 3-ethyl-3-hydroxy-2-(m-tolyl)isoindolin-1-one 

Relevant articles and documents

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature

The unsymmetrical biaryls (Ar1-Ar2) produced by the catalytic cross-couplings of aryl halides (Ar1-halo) with aryl metallics (Ar2-M) in the loading ratio of 1:1 are popular in chemical synthesis. In contrast, there has been less precedence on the same biaryls produced effectively from two normal aryl C-H bonds with equivalent loading. Here, we report that, in a palladium/oxidant/acid catalytic system at room temperature, one arene (Ar1-H, 1 equiv) can highly selectively couple with the other one (Ar2-H, 1 equiv) to afford the target Ar1-Ar2 just by controlling the directing groups and the substituted groups on their phenyl rings. The utility of this one-one cross-coupling is also demonstrated by synthesis of a few bioactive molecules.

PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides

A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.

Synthetic method for N-substituted imide

The invention provides a synthetic method for N-substituted imide. According to the method, aromatic ketone and amine are used as substrates, air or oxygen is used as an oxygen source, and cyclic imide is produced under liquid phase conditions under the action of a catalyst. The method is mild in conditions, high in oxidation efficiency and high in product yield; and since the method uses air or oxygen as the oxygen source, the method is economic and environment-friendly and has good application prospect.