2338-05-8

Basic information

• Product Name: FERRIC CITRATE
• Synonyms: Iron(III) citrate tribasic monohydrate,Ferric citrate monohydrate;IRON(lll) CITRATE, hydrate, tech-95;Ferric Citrate, Powder;Iron(Ⅲ) Citrate n-Hydrate;2,3-propanetricarboxylicacid,2-hydroxy-ironsalt;IRON (III) CITRATE, GREEN;IRON CITRATE;FERRIC CITRATE
• CAS NO: 2338-05-8
• Molecular Formula: C6H5FeO7
• Molecular Weight: 244.94
• EINECS: 219-045-4
• Product Categories: Organic-metal salt
• Mol File: 2338-05-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 309.6oC at 760mmHg
• Flash Point: 155.2oC
• Appearance: /
• Density: 1.906[at 20℃]
• Vapor Pressure: 5.73E-05mmHg at 25°C
• Water Solubility: Soluble in water
• Stability: Stable. Light sensitive.
• Merck: 13,4050
• CAS DataBase Reference: FERRIC CITRATE(CAS DataBase Reference)
• NIST Chemistry Reference: FERRIC CITRATE(2338-05-8)
• EPA Substance Registry System: FERRIC CITRATE(2338-05-8)

Safety Data

• WGK Germany: 3
• F: 8
• Hazardous Substances Data: 2338-05-8(Hazardous Substances Data)

Usage

Description

Ferric Citrate is a nutrient supplement prepared from the reaction of citric acid with ferric hydroxide, resulting in a compound with an indefinite ratio of citric acid and iron. It is also known as iron (III) citrate and is characterized by its red to brown powder appearance.

Uses

Used in Medicine:
Ferric Citrate is used as a nutrient supplement for the treatment of iron deficiency anemia. It helps in increasing the iron levels in the body, which is essential for the production of hemoglobin and maintaining overall health.
Used in Infant Formula:
Ferric Citrate is used as an iron source in infant formula to ensure that infants receive adequate amounts of iron for their growth and development. Iron is crucial for various bodily functions, including oxygen transport and energy production.
Used in Blueprint Paper:
Ferric Citrate is used as a component in the production of blueprint paper, which is a type of paper used for creating architectural and engineering drawings. The chemical properties of ferric citrate make it suitable for this application, as it can help in the development of the blue lines on the paper.

Flammability and Explosibility

Notclassified

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

InChI:InChI=1/C6H8O7.Fe.4H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;4*1H2/q;+3;;;;/p-3

Synthetic route

citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
Stage #1: citric acid With sodium hydroxide In water for 0.5h; Stage #2: With iron(III) chloride hexahydrate In water at 50 - 55℃; for 1h;	85%

iron(III) oxide + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
In water at 75 - 80℃; for 4h;	83.8%

sodium citrate (68-04-2) → ferric citrate (2338-05-8)

Conditions	Yield
With iron(III) chloride hexahydrate In water at 80 - 90℃; for 1h;	78%

ferric nitrate (7782-61-8) + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
In water for 4h; Product distribution / selectivity;	54%
for 4h; Product distribution / selectivity;

iron(III) chloride + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
In ethanol; water for 1h; Product distribution / selectivity;
Stage #1: iron(III) chloride With sodium carbonate In water at 20℃; for 1h; Large scale; Stage #2: In water at 40 - 60℃; Large scale; Stage #3: citric acid In water at 60 - 100℃; for 1h; Large scale;	15.88 kg

iron (III) hydroxide + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
at 80 - 90℃;
at 30 - 90℃; pH=0.8 - 1.5;

iron(III) sulfate + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
In water mixed molar ratio ligand/Fe(3+) of slightly more than 1;

iron(III) chloride hexahydrate + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
Stage #1: iron(III) chloride hexahydrate With sodium hydroxide In water at 25 - 30℃; Large scale; Stage #2: citric acid In water at 80 - 85℃; Large scale;	1.25 kg
Stage #1: iron(III) chloride hexahydrate With sodium carbonate In water at 25 - 30℃; for 1.5h; pH=8 - 8.5; Stage #2: citric acid In water at 25 - 120℃; Reagent/catalyst; Temperature; pH-value;
Stage #1: iron(III) chloride hexahydrate With sodium hydroxide In water at 0 - 10℃; for 4h; Stage #2: citric acid In water at 20 - 85℃; for 2.5h;

iron(II) carbonate (767234-62-8) + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
In water at 80℃;

iron(III)-acetylacetonate (14024-18-1) + citric acid (77-92-9) → ferric citrate (2338-05-8)

Conditions	Yield
In water at 65℃; for 1h;	1.32 g

hydrogen fluoride (7664-39-3) + water (7732-18-5) + piperazinium sulfate (4554-26-1) + ferric citrate (2338-05-8) → 2H2N(CH2)4NH2(2+)*2Fe(3+)*3Fe(2+)*12F(1-)*2SO4(2-)*2H2O=[H2N(CH2)4NH2]2[Fe5F12(SO4)2(H2O)2]

Conditions	Yield
In water; ethylene glycol High Pressure; at 180°C for 2 d at constant pressure in a bomb, Fe:HF:H2O:piperazine sulfate:ethylene glycol=1:8:50:4:50 molar ratio; elem. anal.;	50%

sulfuric acid (7664-93-9) + hydrogen fluoride (7664-39-3) + ferric citrate (2338-05-8) + sodium sulfate (7757-82-6) → sodium ferric(III) fluorosulfate

Conditions	Yield
In water; butan-1-ol at 150℃; for 120h;	45%

1,4-diaza-bicyclo[2.2.2]octane (280-57-9) + sulfuric acid (7664-93-9) + hydrogen fluoride (7664-39-3) + water (7732-18-5) + ferric citrate (2338-05-8) → HN(CH2)6NH(2+)*2Fe(2+)*Fe(3+)*6F(1-)*2SO4(2-)*H(1+)*H2O=[HN(CH2)6NH][Fe3F6(SO4)2]*H3O

Conditions	Yield
In water; butan-1-ol High Pressure; at 180°C for 2 d at constant pressure in a bomb, Fe:H2SO4:HF:H2O:DABCO:n-butanol=1:4:4:50:6:30 molar ratio; elem. anal.;	40%

sulfuric acid (7664-93-9) + hydrogen fluoride (7664-39-3) + water (7732-18-5) + ferric citrate (2338-05-8) + 1,5-diamino-3-azapentane (111-40-0) → 4NH3CH2CH2NH2CH2CH2NH3(3+)*9Fe(2+)*18F(1-)*6SO4(2-)*9H2O=(NH3CH2CH2NH2CH2CH2NH3)4(Fe9F18(SO4)6)*9H2O

Conditions	Yield
In ethanol; water High Pressure; mixt. iron(III) citrate, H2SO4, HF, diethylenetriamine, EtOH and water (pH 4) was stirred for 2 h and heated in PTFE-lined acid-digestion bomb at 180°C for 4 days; react. mixt. was cooled to room temp., ppt. was filtered and washed withwater and EtOH;	30%

2-ethyl-3-hydroxy-4-pyranone (4940-11-8) + ferric citrate (2338-05-8) → 2C6H5O7(3-)*3C7H7FeO3(2+)

Conditions	Yield
In ethanol; water for 0.25h;

mer-tris(3-hydroxy-2-methyl-4H-pyran-4-onato)iron(III) (115648-45-8, 181656-66-6, 33725-54-1) + ferric citrate (2338-05-8) + citric acid (77-92-9) → ferric monomaltol citrate

Conditions	Yield
In water Heating / reflux;

Maltol (118-71-8) + ferric citrate (2338-05-8) → Reaxys ID: 11390965

Conditions	Yield
With sodium hydroxide In water at 20℃; pH=11.6; Product distribution / selectivity;

ferric citrate (2338-05-8) → iron(III) oxide

Conditions	Yield
In water spray pyrolysis of an aq. ferric citrate soln. on a heated glass substrate;

ferric citrate (2338-05-8) → iron(III) oxide

Conditions	Yield
ferric citrate decomp. in air at 773 K;
In neat (no solvent, solid phase) decompose (air), at 723 K for 3 h; XRD;

strontium(II) carbonate (1633-05-2) + ferric citrate (2338-05-8) → strontium ferrite

Conditions	Yield
With citric acid In water byproducts: CO2; stoich. amt. of SrCO3 and ferric citrate dissolved in citric acid aq. soln. at 80°C; soln. slowly evapd.; residue heated at 200°C for 20 h; calcined at 1000°C for 1 h;

gadolinium(III) oxide + ferric citrate (2338-05-8) + citric acid (77-92-9) → gadolinium iron garnet

Conditions	Yield
In water excess citric acid; refluxed for 6 h; dried at 120°C; heated at 400°C for 24 h in 95%N2/5%O2, then 24 h at 400°C in air, then 1t 400 - 900°C for 4 h or heated in air for 24 h at 400°C, then for 4 h at 500-700°C;

bismuth(III) oxide (1304-76-3) + ferric citrate (2338-05-8) → bismuth ferrite

Conditions	Yield
With ethylene glycol; citric acid In nitric acid mixing of iron citrate soln. with soln. of Bi2O3 in dilute HNO3, addn. of soln. of citric acid and ethylene glycol, stirring at 70-80°C for 6 h, coating on SrTiO3 or LaAlO3 through fast spinning, drying, firing at 780°C in air for 1-12 h;

lanthanum(III) oxide + ferric citrate (2338-05-8) → lanthanum orthoferrite

Conditions	Yield
With citric acid; ethylene glycol In water; nitric acid La2O3, Fe citrate dissolved (HNO3); citric acid in H2O added; mixt. stirred at 60°C for 1 h; ethylene glycol added; stirred at 80°C; gel dried at 150°c for at least 20 h; heat treated at 400-600°C for 3 h; XRD;

barium citrate + ferric citrate (2338-05-8) → barium dodecairon nonadecoxide

Conditions	Yield
In water Fe citrate soln. was added to Ba citrate soln.; heated to dryness at 40°C; glassy brown citrate mixture was heated at temp. between 300 and 800°C; calcined at 600°C for 3 h; pressed into pellets; sintered (800 - 1300°C);
In water mixing of soln. of barium and iron(III) citrates in Ba(2+):Fe(3+)=1:12; ultrazonic spraying at 900°C; firing at 580°C;

manganese(II)carbonate + ferric citrate (2338-05-8) + zinc(II) oxide → MnO(16.6),ZnO(8.6),Fe2O3(74.8) (W%)

Conditions	Yield
With ammonium hydroxide; citric acid In water mixed soln. of educts (citric acid, deionized H2O, 14.8N NH4OH), sprayed by a ultrasonic probe into a 10fold vol. of EtOH, washed (EtOH), filtered, vac. dried at 40-50°C, calcined at 300°C(open vessel, air), 5h, at 900°C(closed), 4h;

manganese(II)carbonate + ferric citrate (2338-05-8) + zinc(II) oxide → MnO(25.2),ZnO(0.3),Fe2O3(74.5) (W%)

Conditions	Yield
With ammonium hydroxide; citric acid In water mixed soln. of educts (citric acid, deionized H2O, 4.8N NH4OH) sprayed by a ultrasonic probe into a 10fold vol. of EtOH, washed(EtOH), filtered, vac. dried at 40-50°C, calcined at 300°C (open vessel, air), 5h, at 900°C (closed), 4h;

manganese(II)carbonate + ferric citrate (2338-05-8) + zinc(II) oxide → MnO(14.1),ZnO(15.8),Fe2O3(70.1) (W%)

Conditions	Yield
With ammonium hydroxide; formic acid In formic acid; water mixed soln. of educts (formic acid, deionized H2O, 14.8N NH4OH) sprayed by a ultrasonic probe into a 10fold vol. of EtOH, washed(EtOH), filtered, vac. dried at 40-50°C, calcined at 300°C (open vessel, air), 5h, at 900°C (closed), 4h;

manganese(II)carbonate + ferric citrate (2338-05-8) + zinc(II) oxide → MnO(6.6),ZnO(23.7),Fe2O3(69.7) (W%)

Conditions	Yield
With ammonium hydroxide; citric acid In water mixed soln. of educts (citric acid, deionized H2O, 14.8N NH4OH) sprayed by a ultrasonic probe into a 10fold vol. of EtOH, washed(EtOH), filtered, vac. dried at 40-50°C, calcined at 300°C (open vessel, air), 5h, at 900°C (closed), 4h;

manganese(II)carbonate + ferric citrate (2338-05-8) + zinc(II) oxide → MnO(16.0),ZnO(15.5),Fe2O3(68.4) (W%)

Conditions	Yield
With ammonium hydroxide; formic acid In formic acid; water mixed soln. of educts (formic acid, deionized H2O, 14.8N NH4OH) sprayed by a ultrasonic probe into a 10fold vol. of EtOH, washed(EtOH), filtered, vac. dried at 40-50°C, calcined at 300°C(open vessel, air), 5h, at 900°C (closed), 4h;

cobalt(II) acetate (71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7) + barium(II) acetate (543-80-6) + ferric citrate (2338-05-8) + citric acid (77-92-9) → Z-hexaferrite

Conditions	Yield
With aq. ammonia; air In water sol-gel method; Fe salt dissolved in aq. citric acid at 70°C; mixed with stoich. amt. of Ba and Co acetates; NH3 soln. added (pH 6-8); sol dried at 135°C for 6 h; decompd. (600°C, 4 h); heat treated at 1200°C for 6 h in air; satisfactory elem. anal.;

manganese(II) citrate (5968-88-7, 10024-66-5, 10060-26-1, 65128-61-2, 71799-92-3, 85514-17-6) + ferric citrate (2338-05-8) → manganese ferrite

Conditions	Yield
In water aq. soln. of manganese citrate and ferric citrate (Fe:Mn=2:1) mixed, pH=3, heated under reflux at 363 K for 10 h, evapd., citrate precursor decompd. in N2 atmosphere at different time duration and temp.;

nickel citrate + ferric citrate (2338-05-8) → nickel(II) ferrite

Conditions	Yield
In neat (no solvent) sintered at 1100°C for 2 h;

lead(II) nitrate + ferric citrate (2338-05-8) + citric acid (77-92-9) → lead ferrite

Conditions	Yield
In neat (no solvent) lead citrate formed from lead nitrate and citric acid, mixed with ferriccitrate, pH of soln. 2.6, refluxed at 100 °C 12 h, dehydrated fr om ethanol (1:10 ratio) to obtain the citrate precursor; thermal decompn. in air between 773-1073 K; chemical analysis;

Upstream product

• 7782-61-8 ferric nitrate 
• 77-92-9 citric acid 
• 68-04-2 sodium citrate 
• 767234-62-8 iron(II) carbonate 
• 14024-18-1 iron(III)-acetylacetonate 

Relevant articles and documents

MCC: Specific of preparation, correlation of the phase composition and electrodynamic properties

Metal-carbon composites (MCC) were produced by the dissolving of the Fe, Co and Ce nitrates in phenol–formaldehyde resin with further pyrolysis (under heating up to 800 °C). Concentrations of the metal compositions in final MCC were 2, 7 and 15 wt%. Phase

Manufacturing Method of Ferric Citrate

A method of manufacturing is provided for obtaining ferric citrate by a simple drying operation, the ferric citrate having a high purity, a high specific surface area, and a reduced water-soluble organic solvent content. The method of manufacturing ferric citrate, comprises a wet material of ferric citrate, containing the ferric citrate and a water-soluble organic solvent and having a water-soluble organic solvent content within the range of more than 0.3% by mass to 30.0% by mass or less, dried by bringing a gas containing water into contact.

Method for the Synthesis of Ferric Oraganic Compounds

The present invention relates to an improved method for the synthesis of Ferric Citrate and also to provide an amorphous form of Ferric Citrate having an active surface area less than 14 sq.m/g.