234766-97-3

Basic information

• Product Name: Pyridine, 4-(2-phenyl-1H-imidazol-4-yl)-
• CAS NO: 234766-97-3
• Molecular Formula: C14H11N3
• Molecular Weight: 221.261
• Mol File: 234766-97-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-(2-phenyl-1H-imidazol-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-(2-phenyl-1H-imidazol-4-yl)-(234766-97-3)
• EPA Substance Registry System: Pyridine, 4-(2-phenyl-1H-imidazol-4-yl)-(234766-97-3)

Safety Data

• Hazardous Substances Data: 234766-97-3(Hazardous Substances Data)

Upstream product

• 618-39-3 benzamidin 
• 100-52-7 benzaldehyde 
• 670-96-2 2-Phenylimidazole 
• 1120-87-2 4-bromopyridin 
• 5349-17-7 4-bromoacetylpyridine hydrobromide 

Downstream Products

• 405554-88-3 4-(2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine 
• 405554-89-4 4-(5-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine 
• 1450018-72-0 3-methoxy-5-(2-phenyl-5-(pyridine-4-yl)-1H-imidazol-4-yl)pyridine-2-amine 
• 1283092-12-5 methyl 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoate 
• 1283092-21-6 4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzoic acid 
• 1283091-28-0 4-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)aniline 
• 1283092-20-5 N-(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanesulfonamide 
• 1283092-19-2 4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline 
• 1283092-18-1 4-[5-(4-nitrophenyl)-2-phenyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-4-yl]pyridine 
• 1283091-17-7 N-(4-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)phenyl)methanesulfonamide 
• 1283091-05-3 N-(4-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)benzyl)methanesulfonamide 
• 1283092-17-0 N-(4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)benzyl)methanesulfonamide 
• 1283092-16-9 (4-(2-phenyl-4-(pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-5-yl)phenyl)methanamine 
• 1283092-15-8 4-(5-(4-(azidomethyl)phenyl)-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine 

Relevant articles and documents

Modular Synthesis of Di- A nd Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors

A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%-85% yield). A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation-condensation protocol, followed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23%-69%, three steps). This approach was also employed in the synthesis of known inhibitor GSK3037619A.

RAF KINASE INHIBITORS

Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.

Diversity synthesis via C-H bond functionalization: Concept-guided development of new C-arylation methods for imidazoles

Herein, we have formulated the concept of systematic derivatization of a structural motif via C-H bond functionalization. This concept may not only serve as a blueprint for new strategies in diversity synthesis but also provide systematic guidance for the