235420-64-1

Basic information

• Product Name: 4-(allyl-benzyloxycarbonyl-amino)-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 235420-64-1
• Molecular Weight: 374.48
• Mol File: 235420-64-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(allyl-benzyloxycarbonyl-amino)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(allyl-benzyloxycarbonyl-amino)-piperidine-1-carboxylic acid tert-butyl ester(235420-64-1)
• EPA Substance Registry System: 4-(allyl-benzyloxycarbonyl-amino)-piperidine-1-carboxylic acid tert-butyl ester(235420-64-1)

Safety Data

• Hazardous Substances Data: 235420-64-1(Hazardous Substances Data)

Upstream product

• 220394-97-8 4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine 
• 180695-80-1 tert-butyl 4-azidopiperidine-1-carboxylate 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 90633-18-4 4-bromo-1H-piperidine 

Relevant articles and documents

Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: Synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N- (benzyloxycarbonyl)amino)piperidin-1-yl)butanes

(2S)-2-(3-Chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[spiro (2,3-dihydrobenzthiophene-3,4′-piperidin-1′-yl)]butane S-oxide (1b) has been identified as a potent CCR5 antagonist having an IC50 = 10 nM. Herein, structure-activity relationship studies of non-spiro piperidines are described, which led to the discovery of 4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidine derivatives (3-5) as potent CCR5 antagonists.