23555-00-2

Basic information

• Product Name: HOECHST 34580
• Synonyms: HOECHST 34580;HOE 34580;ProaMine;2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-
• CAS NO: 23555-00-2
• Molecular Formula: C₂₇H₂₉N₇
• Molecular Weight: 451.56606
• Product Categories: Benzimidazole
• Mol File: 23555-00-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300℃
• Appearance: Yellow to green/powder
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Soluble in dimethyl sulfoxide, water
• PKA: 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃)
• CAS DataBase Reference: HOECHST 34580(CAS DataBase Reference)
• NIST Chemistry Reference: HOECHST 34580(23555-00-2)
• EPA Substance Registry System: HOECHST 34580(23555-00-2)

Safety Data

• Hazardous Substances Data: 23555-00-2(Hazardous Substances Data)

Usage

General Description

HOECHST 34580 is a fluorescent dye commonly used in cell biology and neuroscience research. It is a blue-emitting dye that binds to DNA and is frequently used for staining cell nuclei in live or fixed cells. HOECHST 34580 is also used to label DNA in organelles such as mitochondria and is a useful tool for visualizing and tracking cellular and subcellular structures. Its high specificity and low cytotoxicity make it a popular choice for fluorescent imaging studies, particularly in the study of cell division and cell cycle progression. Additionally, HOECHST 34580 has been used in the development of diagnostic tools for identifying and quantifying DNA in various biological samples.

Upstream product

• 696581-55-2 4-dimethylamino-1-[5'-imino(ethoxy)methylbenzimidazo-2'-yl]benzene hydrochloride 
• 54998-08-2 4-(4-methylpiperazino)-1,2-diaminobenzene 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 23491-49-8 2-amino-4-<5'-(4''-methylpiperazin-1''-yl)benzimidazol-2'-yl>aniline 
• 17626-40-3 4-cyano-1,2-phenylenediamine 
• 158667-64-2 2-(4-dimethylaminophenyl)-1H-benzimidazole-5-carbonitrile 
• 6393-40-4 4-Amino 3-nitro-benzonitrile 

Relevant articles and documents

Radioprotectors

A compound of the formula (Ib): wherein X is NCH3, Y is N, Z is N, R3 is N(CH3)2, and (a) R1 is CH3, R2, R4 and R5 to R11 are hydrogen or (b) R5 is CH3 and R1, R2, R4 and R6 to R11 are hydrogen, and salts and tautomers thereof.

Basic-substituted 2,6-bisbenzimidazole derivates, a novel class of substances with chemotherapeutic activity

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