23562-78-9

Basic information

• Product Name: 2-(diethylaminomethyl)-4-methoxy-phenol
• Synonyms: o-Cresol, a-(diethylamino)-4-methoxy-(7CI,8CI); NSC 17845
• CAS NO: 23562-78-9
• Molecular Formula: C₁₂H₁₉NO₂
• Molecular Weight: 209.28
• Mol File: 23562-78-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 307.2°Cat760mmHg
• Flash Point: 139.6°C
• Appearance: /
• Density: 1.038g/cm³
• Vapor Pressure: 0.000405mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 2-(diethylaminomethyl)-4-methoxy-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(diethylaminomethyl)-4-methoxy-phenol(23562-78-9)
• EPA Substance Registry System: 2-(diethylaminomethyl)-4-methoxy-phenol(23562-78-9)

Safety Data

• Hazardous Substances Data: 23562-78-9(Hazardous Substances Data)

Usage

General Description

2-(diethylaminomethyl)-4-methoxy-phenol, also known as Octocrylene, is a chemical compound commonly used in sunscreen and other skincare products to absorb ultraviolet (UV) radiation. It works by absorbing and dissipating UV radiation, helping to protect the skin from the damaging effects of the sun. In addition to its UV-absorbing properties, Octocrylene also has antioxidant properties, which can help protect the skin from environmental damage. However, there have been some concerns raised about potential harmful effects of Octocrylene, including skin irritation and potential hormone disruption, so it is important to use products containing this chemical with caution and in accordance with recommended guidelines.

InChI:InChI=1/C12H19NO2/c1-4-13(5-2)9-10-8-11(15-3)6-7-12(10)14/h6-8,14H,4-5,9H2,1-3H3

Upstream product

• 102-53-4 bis-(diethylamino)methane 
• 150-76-5 4-methoxy-phenol 
• 50-00-0 formaldehyd 
• 109-89-7 diethylamine 
• 67-56-1 methanol 

Relevant articles and documents

Ruthenium-Catalyzed Aminomethylation and Methylation of Phenol Derivatives Utilizing Methanol as the C1 Source

A reaction involving ortho-aminomethylation of phenol was developed via ruthenium-catalyzed dehydrogenation of methanol, an environmentally benign C1 building block, without the use of reactive reagents. The reaction was successfully applied to a range of substrates. When naphthol was employed instead of phenol, only methylation was observed. On the basis of various mechanistic studies, we propose that formamide barely participates in the reaction, which mainly occurs through an iminium cation intermediate. The difference in the reactivities of phenol and naphthol is attributable to stronger basicity of naphtholate as a conjugate base owing to its lower aromaticity. Plausible reaction pathways were proposed for both reactions. (Figure presented.).

Preparation and NMR characterization of hydrogen bonding in 2- and 2,6-bis-(N,N-diethylaminomethyl)-4R-phenols

A series of Mannich mono- and di-bases derived from 4-substituted phenols were prepared and investigated by 1H and 13C NMR spectroscopy in chloroform-d1 solution.The chemical shifts of intramolecular hydrogen-bonded protons in Mannich bases depend on the